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Table 1 Prevalence (% [n]) of liver and kidney histopathology in East Greenland polar bears sampled during 1999–2002

From: Are liver and renal lesions in East Greenland polar bears (Ursus maritimus) associated with high mercury levels?

Organ Absent Mild Moderate Severe Age p(F)
Liver (n = 59)      
Multifocally mononuclear cell infiltrations 89 (53) 11 (6) - - n.s.
Portal mononuclear cell infiltrations 85 (50) 8 (5) 7 (4) - n.s.
Lipid granulomas 37 (22) 36 (21) 22 (13) 5 (3) n.s.
Hepatocytic steatosis - 24 (14) 24 (14) 52 (31) n.s.
Ito cell lipid accumulation 36 (21) 14 (8) 19 (11) 31 (19) ** (7.8)
Bile duct proliferation with fibrosis 92 (54) 8 (5) - - *** (15.6)
Kidney (n = 57)      
Glomerular diffuse capillary wall thickening 72 (41) 25 (14) 3 (2) - *** (8)
Glomerular mesangial deposits/sclerosis 22 (13) 39 (22) 39 (22) - * (5.6)
Interstitial fibrosis 75 (42) 12 (7) 13 (8) - *** (49.8)
Tubular epithelial cell hyperplasia 75 (42) 12 (7) 13 (8) - ** (6.7)
Tubular hyalinization/atrophy/dilatation/necrosis 61 (35) 12 (7) 27 (15) - *** (30.8)
Tubular medullar hyaline casts 84 (48) 13 (8) 3 (1) - * (6.6)
Mononuclear cell infiltrations 39 (22) 42 (24) 19 (11) - n.s.
  1. Lesions are divided into groups of absent, mild, moderate and severe. n.s.: individuals with lesions not significantly older (mean age) than individuals without lesions at p > 0.05. *: individuals with lesions significantly older (mean age) than individuals without lesions at p ≤ 0.05, **: at p ≤ 0.01 and ***: at p ≤ 0.001.