Table 1 Prevalence (% [n]) of liver and kidney histopathology in East Greenland polar bears sampled during 1999–2002
Organ | Absent | Mild | Moderate | Severe | Age p(F) |
|---|---|---|---|---|---|
Liver (n = 59) | |||||
Multifocally mononuclear cell infiltrations | 89 (53) | 11 (6) | - | - | n.s. |
Portal mononuclear cell infiltrations | 85 (50) | 8 (5) | 7 (4) | - | n.s. |
Lipid granulomas | 37 (22) | 36 (21) | 22 (13) | 5 (3) | n.s. |
Hepatocytic steatosis | - | 24 (14) | 24 (14) | 52 (31) | n.s. |
Ito cell lipid accumulation | 36 (21) | 14 (8) | 19 (11) | 31 (19) | ** (7.8) |
Bile duct proliferation with fibrosis | 92 (54) | 8 (5) | - | - | *** (15.6) |
Kidney (n = 57) | |||||
Glomerular diffuse capillary wall thickening | 72 (41) | 25 (14) | 3 (2) | - | *** (8) |
Glomerular mesangial deposits/sclerosis | 22 (13) | 39 (22) | 39 (22) | - | * (5.6) |
Interstitial fibrosis | 75 (42) | 12 (7) | 13 (8) | - | *** (49.8) |
Tubular epithelial cell hyperplasia | 75 (42) | 12 (7) | 13 (8) | - | ** (6.7) |
Tubular hyalinization/atrophy/dilatation/necrosis | 61 (35) | 12 (7) | 27 (15) | - | *** (30.8) |
Tubular medullar hyaline casts | 84 (48) | 13 (8) | 3 (1) | - | * (6.6) |
Mononuclear cell infiltrations | 39 (22) | 42 (24) | 19 (11) | - | n.s. |