AhR transcriptional activity in serum of Inuits across Greenlandic districts

Long, Manhai; Deutch, Bente; Bonefeld-Jorgensen, Eva C

doi:10.1186/1476-069X-6-32

Environmental Health

Table 4 Multivate linear regression analysis of AhR-TEQ and POPs

From: AhR transcriptional activity in serum of Inuits across Greenlandic districts

		Nuuk			Sisimiut			Qaanaaq			Tasiilaq			All
Men^a		n	β	p	n	β	p	n	β	p	n	β	p	n	β	p
Σ PCB_14	raw¹	21	-.01	.97	41	-.24	.13	37	-.14	.41	33	-.06	.72	135	-.21	.01
	+age	21	.05	.86	41	-.09	.64	37	.05	.80	33	.03	.87	135	-.16	.11
	+n-3/n-6²	21	-.01	.98	29	-.25	.25	37	-.30	.23	33	-.11	.54	123	-.22	.07
	+age+n-3/n-6	21	.07	.87	29	-.06	.81	37	-.14	.60	33	.01	.98	123	-.16	.21
Σ pesticide	raw	21	.08	.72	41	-.27	.087	37	-.20	.23	37	-.13	.46	139	-.25	<.01
	+age	21	.15	.57	41	-.14	.44	37	-.01	.98	37	-.05	.78	139	-.21	.04
	+n-3/n-6²	21	.16	.61	29	-.34	.13	37	-.49	.06	37	-.20	.23	127	-.37	<.01
	+age+n-3/n-6	21	.22	.53	29	-.20	.39	37	-.30	.32	37	-.09	.60	127	-.31	.01
Σ POP	raw¹	21	.04	.86	41	-.26	.10	37	-.19	.24	33	-.11	.56	135	-.16	.01
	+age	21	.11	.69	41	-.12	.50	37	-.01	.96	33	-.02	.93	135	-.20	.06
	+n-3/n-6²	21	.09	.78	29	-.30	.17	37	-.48	.07	33	-.15	.40	123	-.29	.02
	+age+n-3/n-6	21	.16	.66	29	-.15	.54	37	-.29	.31	33	-.04	.82	123	-.23	.06
Women^b
Σ PCB_14	raw¹	12	.06	.85	32	.23	.20	32	-.46	.01	43	-.09	.55	119	-.04	.70
	+age	12	-.01	.99	32	.25	.24	32	-.40	.05	43	-.21	.35	119	-.002	.99
	+n-3/n-6²	12	.58	.19	28	.17	.43	32	-.32	.18	43	-.13	.50	115	.06	.62
	+age+n-3/n-6	12	.53	.31	28	.20	.38	32	-.25	.36	43	-.23	.35	115	.08	.53
Σ pesticide	raw¹	12	.11	.74	32	.25	.16	32	-.53	<.01	44	-.11	.46	120	-.06	.52
	+age	12	.06	.89	32	.26	.19	32	-.50	.01	44	-.28	.20	120	-.03	.74
	+n-3/n-6²	12	.69	.12	28	.19	.39	32	-.51	.04	44	-.17	.35	116	.01	.97
	+age+n-3/n-6	12	.65	.20	28	.20	.37	32	-.47	.09	44	-.31	.19	116	.02	.89
Σ POP	raw¹	12	.09	.79	32	.24	.18	32	-.51	<.01	43	-.11	.49	119	-.05	.57
	+age	12	.03	.95	32	.25	.22	32	-.48	.02	43	-.24	.28	119	-.02	.83
	+n-3/n-6²	12	.66	.14	28	.17	.42	32	-.47	.07	43	-.15	.43	115	.04	.77
	+age+n-3/n-6	12	.62	.23	28	.20	.39	32	-.42	.14	43	-.27	.27	115	.05	.67
Men + Women^c
Σ PCB_14	raw¹	33	-.19	.29	74	-.05	.65	70	-.32	.01	77	-.10	.40	254	-.15	.02
	+age	33	-.09	.79	74	.03	.83	70	-.22	.01	77	-.07	.65	254	-.10	.18
	+n-3/n-6²	33	.12	.72	58	-.15	.30	70	-.34	.02	77	-.15	.24	238	-.16	.06
	+age+n-3/n-6	33	.24	.60	58	-.09	.53	70	-.26	.09	77	-.11	.49	238	-.12	.17
Σ pesticide	raw¹	33	-.13	.47	74	-.07	.58	70	-.38	<.01	82	-.12	.28	254	-.18	<.01
	+age	33	.06	.84	74	.01	.94	70	-.30	.03	82	-.12	.38	254	-.13	.07
	+n-3/n-6²	33	.29	.37	58	-.16	.29	70	-.47	<.01	82	-.21	.09	238	-.24	<.01
	+age+n-3/n-6	33	.41	.29	58	-.12	.44	70	-.40	.02	82	-.17	.22	238	-.21	.02
Σ POP	raw¹	33	-.16	.38	74	-.06	.59	70	-.37	<.01	77	-.12	.30	254	-.17	.01
	+age	33	-.001	.997	74	.01	.92	70	-.29	.04	77	-.10	.49	254	-.12	.09
	+n-3/n-6²	33	.23	.50	58	.16	.28	70	-.45	<.01	77	-.18	.17	238	-.20	.02
	+age+n-3/n-6	33	.36	.395	58	-.11	.46	70	-.31	.02	77	-.14	.36	238	-.16	.07

The analyses were performed on ln transformed data with AhR-TEQ as dependent and POPs as independent variables before and upon adjusted for the potential confounders.
¹: non-adjusted data.
²: ratio of n-3 to n-6 fatty acids in serum.
^a: Combining districts is not allowed according to the multiple regression analyses.
^b: Combining districts is not allowed according to the multiple regression analyses.
^c: According to the multiple regression analyses, combining sex for each district is allowed while combining sexes for all districts is not allowed.
For Σ PCB_14, Σ pesticide and Σ POP, AhR-TEQ, see the legend of Table 2 and Table 3

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ISSN: 1476-069X

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