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Table 4 The effect of quartiles of arsenic on logged urinary 8-OHdG (μg/l) by GSTM1 genotype (N = 290)

From: GSTM1 and APE1 genotypes affect arsenic-induced oxidative stress: a repeated measures study

  GSTM1 positive GSTM1 null Wald p-value LRT p-value††
Model* β 95% CI β 95% CI   
Total urinary arsenic quartile (μg/l)       0.007
1.35 – 13.3 reference   reference    
>13.3 – 22.6 -0.12 (-0.46, 0.22) 0.84 (0.27, 1.42) 0.004  
>22.6 – 47.9 -0.06 (-0.43, 0.31) 0.98 (0.33, 1.66) 0.005  
>47.9 – 431.3 -0.15 (-0.60, 0.30) 0.85 (0.27, 1.44) 0.004  
Drinking water arsenic quartile (μg/l)       0.69
0.5 reference   reference    
>0.50 – 1.5 -0.05 (-0.42, 0.31) 0.26 (-0.41, 0.93) 0.43  
>1.5 – 81.7 0.29 (-0.11, 0.69) 0.15 (-0.46, 0.75) 0.69  
>81.7 – 591 -0.21 (-0.66, 0.24) 0.002 (-0.74, 0.75) 0.63  
Toenail arsenic quartile (μg/g)       0.69
0.2 – 0.6 reference   reference    
>0.6 – 0.8 -0.19 (-0.71, 0.33) -0.09 (-0.93, 0.75) 0.83  
>0.8 – 1.6 -0.36 (-0.87, 0.14) -0.22 (-1.06, 0.63) 0.77  
>1.6 – 10.2 -0.49 (-1.00, 0.03) 0.05 (-0.76, 0.87) 0.26  
  1. *Main effects are from three random effects Tobit models adjusted for logged creatinine, BMI, age, betelnut chewing, environmental tobacco smoke, and education (secondary or higher vs primary or less), and hOGG1 and APE1 genotypes.
  2. significance test for individual interaction terms.
  3. †† significance test for the entire group of arsenic quartile by gene interactions