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Table 3 Joint effects of GST genotype and drinking water level of arsenic on Case Status

From: A case-control study of GST polymorphisms and arsenic related skin lesions

    

Overall Joint Effects

  

Joint Effects Stratified on Exposure

Joint Effects Stratified on Genotype

 

As Level of Well

Controls (N)

Cases (N)

OR (95%CI)

p-value

ICR

95%CL

OR (95%CI)

p-value

OR (95%CI)

p-value

GSTT1

           

Null

low

85

52

1.0

   

1.0

 

1.0

 

Wildtpe

low

376

272

1.62 (1.06–2.49)

0.03

  

1.62 (1.06–2.49)

0.03

1.0

 

null

high

27

48

3.16 (1.71–5.85)

0.0002

  

1.0

 

3.16 (1.71–5.85)

0.0002

Wildtpe

high

106

222

3.64 (2.31–5.74)

<0.0001

  

1.15 (0.68–1.94)

0.60

2.24 (1.69–2.98)

<0.0001

      

0.94

(-2.08–1.83)

    

GSTM1

           

Null

low

189

126

1.0

   

1.0

 

1.0

 

Wildtype

low

272

198

1.02 (0.74–1.40)

0.91

  

1.02 (0.74–1.40)

0.91

1.0

 

Null

high

55

117

2.62 (1.77–3.90)

<0.0001

  

1.0

 

2.62 (1.77–3.90)

<0.0001

Wildtype

high

78

151

2.24 (1.56–3.22)

<0.0001

  

0.85 (0.57–1.29)

0.85

2.20 (1.57–3.09)

<0.0001

      

1.02

(-2.40–1.57)

    

GSTP1

           

AA

low

246

180

1.0

   

1.0

 

1.0

 

AG

low

184

110

0.81 (0.58–1.14)

0.23

  

0.81 (0.58–1.14)

0.23

1.0

 

GG

low

26

32

2.32 (1.31–4.09)

0.004

  

2.32 (1.31–4.09)

0.004

1.0

 

AA

high

67

138

2.27 (1.60–3.22)

<0.0001

  

1.0

 

2.27 (1.60–3.22)

<0.0001

AG

high

52

108

2.49 (1.69–3.68)

<0.0001

0.85

(-2.13–1.51)

1.10 (0.72–1.69)

0.67

3.06 (2.01–4.66)

<0.0001

GG

high

10

20

2.38 (1.11–5.13)

0.03

1.68

(-2.15–1.83)

1.04 (0.48–2.31)

0.90

1.03 (0.41–2.55)

0.95

  1. All models adjusted for liters of liquid/day, age, gender, educational status, BMI, chewing tobacco, betel nut use, smoking status, and previous well use