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Table 3 Joint effects of GST genotype and drinking water level of arsenic on Case Status

From: A case-control study of GST polymorphisms and arsenic related skin lesions

     Overall Joint Effects    Joint Effects Stratified on Exposure Joint Effects Stratified on Genotype
  As Level of Well Controls (N) Cases (N) OR (95%CI) p-value ICR 95%CL OR (95%CI) p-value OR (95%CI) p-value
GSTT1            
Null low 85 52 1.0     1.0   1.0  
Wildtpe low 376 272 1.62 (1.06–2.49) 0.03    1.62 (1.06–2.49) 0.03 1.0  
null high 27 48 3.16 (1.71–5.85) 0.0002    1.0   3.16 (1.71–5.85) 0.0002
Wildtpe high 106 222 3.64 (2.31–5.74) <0.0001    1.15 (0.68–1.94) 0.60 2.24 (1.69–2.98) <0.0001
       0.94 (-2.08–1.83)     
GSTM1            
Null low 189 126 1.0     1.0   1.0  
Wildtype low 272 198 1.02 (0.74–1.40) 0.91    1.02 (0.74–1.40) 0.91 1.0  
Null high 55 117 2.62 (1.77–3.90) <0.0001    1.0   2.62 (1.77–3.90) <0.0001
Wildtype high 78 151 2.24 (1.56–3.22) <0.0001    0.85 (0.57–1.29) 0.85 2.20 (1.57–3.09) <0.0001
       1.02 (-2.40–1.57)     
GSTP1            
AA low 246 180 1.0     1.0   1.0  
AG low 184 110 0.81 (0.58–1.14) 0.23    0.81 (0.58–1.14) 0.23 1.0  
GG low 26 32 2.32 (1.31–4.09) 0.004    2.32 (1.31–4.09) 0.004 1.0  
AA high 67 138 2.27 (1.60–3.22) <0.0001    1.0   2.27 (1.60–3.22) <0.0001
AG high 52 108 2.49 (1.69–3.68) <0.0001 0.85 (-2.13–1.51) 1.10 (0.72–1.69) 0.67 3.06 (2.01–4.66) <0.0001
GG high 10 20 2.38 (1.11–5.13) 0.03 1.68 (-2.15–1.83) 1.04 (0.48–2.31) 0.90 1.03 (0.41–2.55) 0.95
  1. All models adjusted for liters of liquid/day, age, gender, educational status, BMI, chewing tobacco, betel nut use, smoking status, and previous well use