Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study

De Coster, Sam; Koppen, Gudrun; Bracke, Marc; Schroijen, Carmen; Den Hond, Elly; Nelen, Vera; Van de Mieroop, Els; Bruckers, Liesbeth; Bilau, Maaike; Baeyens, Willy; Schoeters, Greet; van Larebeke, Nik

doi:10.1186/1476-069X-7-26

Environmental Health

Table 6 Associations between effect biomarkers and exposure information derived from questionnaires.

From: Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study

Effect biomarker	n	Parameter of exposure	Confounding factors	Regression coefficient	Standerdized regression coefficient (95% CI)	Squared semi-partial correlation	p-value
PSA ng/mL (n = 770)	770	Consumption of dairy fat	A/S/LS/BMI	0.009	0.071 (0.001, 0.142)	0.005	0.047
CEA ng/mL (n = 829)	829	Lifetime smoking	A/S	0.064	0.429 (0.313, 0.546)	0.048	< 0.000001
		Consumption of Alcohol	A/S/LS	0.030	0.174 (0.110, 0.237)	0.027	< 0.000001
		Exposure to solvents	A/S/LS	0.383	0.100 (0.038, 0.161)	0.010	0.0015
		Recent alcohol consumption	A/S/LS	0.046	0.096 (0.033, 0.160)	0.008	0.0029
		Consumption of fish fat	A/S/LS	0.070	0.069 (0.008, 0.131)	0.005	0.027
		Exposure to halogenated hydrocarbons	A/S/LS	0.266	0.068 (-0.080, 0.216)	0.005	0.030
p53 pg/mL	825	Consumption of fish fat	A/S/LS	9.836	0.097 (0.028, 0.166)	0.009	0.0059
		Consumption of fruit	A/S/LS	0.115	0.098 (0.029, 0.167)	0.009	0.0056
Micronuclei (number per 1000 binucleated cells)	773	Consumption of fish fat	A/S/LS	0.312	0.108 (0.043, 0.173)	0.011	0.0011
		Consumption of vegetables	A/S/LS	0.003	0.089 (0.024, 0.153)	0.008	0.0072
DNA strand breaks (%DNA, comet assay)	593	Consumption of meat fat	A/S/RS	-0.018	-0.125 (-0.208, -0.042)	0.014	0.0033
		Indoor stoking of diverse organic materials	A/S/RS	0.228	0.111 (0.030, 0.191)	0.012	0.0072
		Exposure to solvents	A/S/RS	0.208	0.102 (0.020, 0.184)	0.010	0.015
		Consumption of freshwater fish	A/S/RS	-0.447	-0.098 (-0.178, -0.018)	0.010	0.017
		Nuisance from noise (day)	A/S/RS	0.124	0.094 (0.014, 0.175)	0.009	0.022
		Nuisance from noise (night)	A/S/RS	0.170	0.087 (0.006, 0.167)	0.007	0.036
		Exposure to halogenated hydrocarbons	A/S/RS	0.179	0.086 (0.005, 0.167)	0.007	0.039

A multiple regression was performed with each effect biomarker as dependent variable with a measured exposure variable and confounding factors as independent variables. CI: confidence interval, n: number of cases, A = age, S = sex, LS = lifetime smoking, RS = recent smoking, BMI = body mass index.

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ISSN: 1476-069X

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