Immune cell counts and risks of respiratory infections among infants exposed pre- and postnatally to organochlorine compounds: a prospective study

Table 4 Regression coefficients for associations between organochlorine exposure prenatally and numbers and percentages of white blood cells and lymphocyte subsets^a

	CB 153	Di-ortho PCB	Mono-ortho PCB TEQ	p,p'-DDE
White blood cell count^b	0.01 ± 0.52	0.04 ± 0.54	0.31 ± 0.45	0.46 ± 0.36
Neutrophil numbers^b	0.04 ± 0.18	0.05 ± 0.18	0.08 ± 0.15	-0.03 ± 0.12
Neutrophil %^b	1.11 ± 2.27	1.09 ± 2.23	0.36 ± 1.85	-0.80 ± 1.51
Eosinophil numbers^b	-0.00 ± 0.04	0.001 ± 0.04	0.01 ± 0.03	-0.06 ± 0.03
Eosinophil %^b	0.05 ± 0.57	0.02 ± 0.59	0.002 ± 0.49	-1.06 ± 0.38*
Eosinophil %^c				-1.62 ± 0.46*
Lymphocyte numbers^b	-0.03 ± 0.41	-0.01 ± 0.43	0.17 ± 0.35	0.48 ± 0.28
Lymphocyte %^b	-1.05 ± 2.31	-1.07 ± 2.39	0.06 ± 1.99	1.41 ± 1.61
Monocyte numbers^b	0.004 ± 0.05	0.01 ± 0.05	-0.01 ± 0.04	0.04 ± 0.03
Monocyte %^b	0.24 ± 0.51	0.32 ± 0.53	-0.15 ± 0.44	0.36 ± 0.36
CD19⁺ numbers^b	-0.07 ± 0.16	-0.06 ± 0.16	-0.07 ± 0.15	0.03 ± 0.11
CD19⁺ %^b	-0.41 ± 2.55	0.05 ± 2.6	0.87 ± 2.3	-0.81 ± 1.7
CD3⁺ numbers^b	-0.08 ± 0.46	-0.05 ± 0.47	-0.19 ± 0.42	0.42 ± 0.30
CD3⁺ %^b	-3.33 ± 4.09	-2.9 ± 4.2	-3.1 ± 3.8	-0.89 ± 2.8
CD4⁺CD8^- numbers^b	0.04 ± 0.36	0.13 ± 0.37	0.05 ± 0.33	0.29 ± 0.24
CD4⁺CD8^- %^b	-0.18 ± 3.89	0.17 ± 4.02	0.03 ± 3.68	-0.63 ± 2.70
CD4^-CD8⁺ numbers^b	-0.22 ± 0.08	-0.24 ± 0.09	-0.19 ± 0.08	-0.15 ± 0.06
CD4^-CD8⁺ %^b	-3.54 ± 1.19*	-3.84 ± 1.23*	-3.28 ± 1.12*	-1.98 ± 0.92
CD4^-CD8⁺ %^c	-3.69 ± 1.93	-4.08 ± 2.05	-4.91 ± 2.05
CD56⁺ numbers^b	0.01 ± 0.01	0.01 ± 0.01	0.003 ± 0.009	0.003 ± 0.007
CD56⁺ %^b	0.27 ± 0.18	0.24 ± 0.19	0.18 ± 0.17	0.07 ± 0.13

^aInfants with an ongoing infection at the time of sampling were excluded, as well as infants that had an infection within 7 days before sampling. Prenatal exposure: lipid adjusted mother's serum organochlorine compound concentrations in late pregnancy (week 32–34). Di-ortho PCB = CB-138, CB-153, CB-180; Mono-ortho PCB TEQ = CB-105, CB-118, CB-156, CB-167 [32]. White blood cell counts: N = 75–79. Lymphocyte subsets: N = 45–50.
^bRegression coefficients from simple regression analysis (mean ± SE)
^cPartial regression coefficients (mean ± SE) adjusted for age of the mother, smoking and alcohol during pregnancy, mother's education, vaccination of the infant, nursing of the infant, age of the infant, and infant's history of respiratory infections.
*p ≤ 0.01.

ISSN: 1476-069X