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Table 3 Linear regression analysis of log(triglycerides) on 2,4-D and covariates for ages 20-59, NHANES III, 1988-1994.

From: Perturbation of lipids and glucose metabolism associated with previous 2,4-D exposure: a cross-sectional study of NHANES III data, 1988-1994

Independent variables All available subjects (n = 708) Susceptible subpopulations
   HbA1c > 5.1% T4 ≤ 8.5 μg/dl
   (n = 345) (n = 344)
  Estimate (95% CI) Estimate (95% CI) Estimate (95% CI)
Intercept 6.993 6.575 6.976
  (6.296, 7.690)a (5.525, 7.624)a (5.929, 8.023)a
2,4-D, binary 1.804 3.119 1.791
  (0.410, 3.199)c (0.958, 5.279)b (-0.180, 3.761)
Log(HDL) for 2,4-D < LOD -0.644 -0.570 -0.660
  (-0.791, -0.497)a (-0.798, -0.342)a (-0.879, -0.440)a
Log(HDL) for 2,4-D ≥ LOD -1.119 -1.378 -1.150
  (-1.467, -0.771)a (-1.908, -0.847)a (-1.635, -0.664)a
Log (urinary creatinine) -0.026 -0.001 0.006
  (-0.080, 0.028) (-0.082, 0.081) (-0.076, 0.088)
Gender 0.034 0.004 0.006
  (-0.043, 0.112) (-0.111, 0.120) (-0.114, 0.126)
Age (years) 0.007 0.008 0.008
  (0.004, 0.011)a (0.003, 0.013)b (0.003, 0.013)b
Non-Hispanic Black -0.130 -0.119 -0.160
  (-0.219, -0.041)b (-0.255, 0.016) (-0.292, -0.027)c
Mexican American 0.079 0.130 0.099
  (-0.014, 0.172) (-0.016, 0.276) (-0.053, 0.251)
Other ethnicity 0.185 0.077 0.359
  (-0.033, 0.402) (-0.226, 0.380) (0.040, 0.677)c
Past smoker 0.019 -0.012 0.040
  (-0.079, 0.117) (-0.154, 0.130) (-0.104, 0.183)
Active smoker 0.103 0.028 0.080
  (0.022, 0.183)b (-0.093, 0.148) (-0.043, 0.202)
BMI 25-29 kg/m2 0.242 0.245 0.296
  (0.159, 0.325)a (0.117, 0.373)a (0.173, 0.419)a
BMI ≥ 30 kg/m2 0.346 0.277 0.315
  (0.248, 0.444)a (0.140, 0.415)a (0.162, 0.468)a
Alcohol consumption 0.056 0.094 0.050
  (-0.071, 0.184) (-0.088, 0.275) (-0.117, 0.217)
Income ≥ 20K (%) -0.015 0.045 0.003
  (-0.090, 0.060) (-0.064, 0.154) (-0.113, 0.119)
Hours of fasting -0.014 -0.013 -0.020
  (-0.022, -0.006)a (-0.025, -0.001)c (-0.032, -0.007)b
  1. a p ≤ 0.001, b p ≤ 0.01, c p ≤ 0.05
  2. P-values for the interaction term log(HDL)*2,4-D are 0.01 for all subjects, 0.005 for subjects with HbA1c > 5.1%, and 0.06 for subjects with T4 ≤ 8.5 μg/dl.