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Table 8 Linear regression analysis of log(TSH) on 2,4-D and covariates for ages 20-59, NHANES III, 1988-1994.

From: Perturbation of lipids and glucose metabolism associated with previous 2,4-D exposure: a cross-sectional study of NHANES III data, 1988-1994

Independent variables All available subjects (n = 705) Susceptible subpopulations
   HbA1c > 5.1% T4 ≤ 8.5 μg/dl
   (n = 343) (n = 342)
  Estimate (95% CI) Estimate (95% CI) Estimate (95% CI)
Intercept -0.487 0.134 -1.263
  (-1.380, 0.407) (-1.235, 1.503) (-2.587, 0.061)
2,4-D, binary 1.380 -0.915 2.537c
  (-0.395, 3.154) (-3.689, 1.858) (0.066, 5.007)c
Log(HDL) for 2,4-D < LOD 0.209 0.125 0.309
  (0.021, 0.397) (-0.172, 0.422) (0.032, 0.585)c
Log(HDL) for 2,4-D ≥ LOD -0.177 0.360 -0.371
  (-0.620, 0.266) (-0.321, 1.042) (-0.981, 0.239)
Log(urinary creatinine) -0.010 -0.029 0.067
  (-0.079, 0.059) (-0.135, 0.076) (-0.036, 0.170)
Gender 0.024 0.052 0.004
  (-0.075, 0.123) (-0.097, 0.202) (-0.147, 0.155)
Age (years) 0.004 0.002 0.007
  (-0.000, 0.009) (-0.005, 0.009) (0.000, 0.014)c
Non-Hispanic Black -0.264 -0.312 -0.346
  (-0.377, -0.151)a (-0.486, -0.138)a (-0.512, -0.180)a
Mexican American -0.126 -0.227 -0.167
  (-0.244, -0.007)c (-0.415, -0.040)c (-0.357, 0.023)
Other ethnicity -0.046 -0.072 -0.111
  (-0.331, 0.238) (-0.477, 0.334) (-0.527, 0.306)
Past smoker -0.049 -0.192 -0.076
  (-0.174, 0.076) (-0.374, -0.010)c (-0.256, 0.104)
Active smoker -0.117 -0.260 -0.080
  (-0.220, -0.014)c (-0.416, -0.103)b (-0.235, 0.075)
BMI 25-29 kg/m2 0.100 0.106 0.215
  (-0.005, 0.206) (-0.059, 0.271) (0.061, 0.369)b
BMI ≥ 30 kg/m2 0.148 0.156 0.304
  (0.023, 0.274)c (-0.024, 0.336) (0.111, 0.498)b
Alcohol consumption -0.005 0.032 -0.003
  (-0.167, 0.157) (-0.202, 0.263) (-0.212, 0.207)
Income ≥ 20K (%) -0.036 -0.053 0.015
  (-0.132, 0.059) (-0.193, 0.087) (-0.130, 0.161)
Hours of fasting 0.002 -0.001 -0.011
  (-0.009, 0.012) (-0.016, 0.015) (-0.026, 0.005)
  1. a p ≤ 0.001, b p ≤ 0.01, c p ≤ 0.05
  2. P-values for the interaction term log(HDL)*2,4-D are 0.10 for all subjects, 0.52 for subjects with HbA1c > 5.1%, and 0.04 for subjects with T4 ≤ 8.5 μg/dl.