HFE Gene Variants Modify the Association between Maternal Lead Burden and Infant Birthweight: A Prospective Birth Cohort Study in Mexico City, Mexico

Table 4 Adjusted parameter estimates for the association of HFE H63 D and TF P570 S genotype status and birthweight, in separate linear regression models^a

Model	Variable	N	β	95% CI
1	Infant HFE H63 D Genotype	367	-129.5**	-236.4, -22.6
2	Infant TF P570 S Genotype	371	34.9	-68.3,138.2
3	Maternal HFE H63 D Genotype^b	502	-53.7	-148.9, 41.5
4	Maternal TF P570 S Genotype^b	503	-62.6	-148.5, 23.4
5	H63_Inf. Wildtype/H63_Mat.Wildtype	Referent (N = 260)
	H63_Inf. Wildtype/H63D_Mat.Variant	16	94.7	-99.0, 288.4
	H63D_Inf. Variant/H63_Mat.Wildtype	24	-77.4	-240.9, 86.1
	H63D_Inf. Variant/H63D_Mat.Variant	32	-176.9**	-318.6, -35.3
6	TF_Inf. Wildtype/TF_Mat.Wildtype	Referent (N = 252)
	TF_Inf. Wildtype/TF_Mat.Variant	31	-63.2	-207.2, 80.8
	TF_Inf. Variant/TF_Mat.Wildtype	27	66.9	-88.6, 222.3
	TF_Inf. Variant/TF_Mat.Variant	27	-36.4	-190.1,117.2

^aAll models are adjusted for maternal age, years of maternal education, infant gender, maternal arm circumference, gestational age, smoking status during pregnancy, marital status, maternal tibia lead, maternal hemoglobin at 1 month post-partum, and parity.
^bAll models additionally adjusted for maternal age², and dummy variables for maternal education (years of education: <8, 8 -11, 11>) to account for the non-linear nature of these covariates.
** P-value < 0.05, * P-value < 0.1
Infant - Inf., Maternal - Mat. Number - N, Coefficient - Coef., Confidence Interval - CI

ISSN: 1476-069X