Effect modification of air pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions

Ren, Cizao; Vokonas, Pantel S; Suh, Helen; Fang, Shona; Christiani, David C; Schwartz, Joel

doi:10.1186/1476-069X-9-78

Environmental Health

Table 2 Genotype distribution of participants (N = 320)*

From: Effect modification of air pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions

Polymorphism	Type	Count (%)	Polymorphism	Type	Count (%)
CAT (C/T) rs480575	Wild	138 (49.46)	HFE (G/A) rs1800562	Wild	259 (86.33)
	Heterozygous	113 (40.5)		Heterozygous	41 (13.67)
	Homozygous	28 (10.04)		Homozygous	0 (0)
CAT(A/G) rs1001179	Wild	195 (65.88)	HMOX (A/T) rs2071746	Wild Type	87 (29.49)
	Heterozygous	83 (28.04)		Heterozygous	148 (50.17)
	Homozygous	18 (6.08)		Homozygous	60 (20.34)
CAT(G/A) rs2284367	Wild	160 (55.17)	HMOX (C/G) rs2071747	Wild Type	269 (91.5)
	Heterozygous	109 (37.59)		Heterozygous	25 (8.5)
	Homozygous	21 (7.24)		Homozygous	0 (0)
CAT (A/G) rs2300181	Wild	165 (55.37)	HMOX (G/A) rs2071749	Wild Type	92 (30.77)
	Heterozygous	110 (36.91)		Heterozygous	154 (51.51)
	Homozygous	23 (7.72)		Homozygous	53 (17.73)
GC (C/A) rs2282679	Wild	150 (51.02)	HMOX (C/G) rs5995098	Wild Type	141 (47.32)
	Heterozygous	120 (40.82)		Heterozygous	128 (42.95)
	Homozygous	24 (8.16)		Homozygous	29 (9.73)
GC (T/C) rs1155563	Wild	148 (49.83)	GSTP1 (A/G) rs1695	Wild Type	149 (50.51)
	Heterozygous	128 (43.10)		Heterozygous	123 (41.69)
	Homozygous	21 (7.07)		Homozygous	23 (7.80)
GCLC (C/T) rs17883901	Wild	262 (89.12)	GSTP1 (C/T) rs1799811	Wild Type	254 (86.39)
	Heterozygous	30 (10.20)		Heterozygous	39 (13.27)
	Homozygous	2 (0.68)		Homozygous	1 (0.34)
GCLM (A/G) rs2301022	Wild	116 (39.59)	GSTT1	Deletion	53 (19.13)
	Heterozygous	146 (49.83)		Non deletion	224 (80.87)
	Homozygous	31 (10.58)	GSTM1	Deletion	152 (51.18)
GCLM (A/G) rs3170633	Wild	140 (48.28)		Non deletion	145 (48.82)
	Heterozygous	115 (39.66)	HMOX-1	Both short	21 (6.98)
	Homozygous	35 (12.07)		One short	140 (46.51)
HFE (G/T) rs1799945	Wild	224 (74.17)		Both long	140 (46.51)
	Heterozygous	71 (23.51)
	Homozygous	7 (2.32)

*The sum of the subjects in each genotype may not add up to the total number of subjects due to missing genotyping data. Missing genotyping is due to a variable number of samples for each locus for which genotyping was not successful.

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ISSN: 1476-069X

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