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Fig. 1 | Environmental Health

Fig. 1

From: Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure

Fig. 1

Alterations in hepatocyte nuclear architecture in female Roundup-treated rats suggests transcriptional disturbances. Liver from control (C) and Roundup (R) treated female rats were subjected to an ultrastructural electron microscopic analysis to investigate subcellular architecture. a Quantification of morphometric analysis of hepatocytes revealing alterations in subnuclear (heterochromatin, dense fibrillar, granular) compartments indicative of a reduced transcriptional status. Morphometric parameters are represented by their mean and their standard deviation. A two-tailed unpaired t-test was used as a standard test for statistical comparisons (***, p <0.001). b Representative electron micrographs comparing hepatocytes from control (upper panel) and Roundup-treated (lower panel) rats showing a disruption of glycogen dispersion (G). N nucleus, R rough endoplasmic reticulum

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