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Table 3 Analyses of temporal clustering of neuroblastic tumours at ages <18 months in the NRYPMDRa

From: Temporal clustering of neuroblastic tumours in children and young adults from Northern England

  \( \widehat{\upbeta} \)b (SE)c
  one-sided P-value d
Type of analysis Within months Within quarters Within years Within full study period
Between fortnightse 1.532 (0.866) 0.562 (0.255) 0.215 (0.082) 0.097 (0.044)
  P = 0.038 P = 0.018 P = 0.016 P = 0.025
Between months   0.300 (0.387) 0.133 (0.118) 0.043 (0.062)
   P = 0.18 P = 0.12 P = 0.18
Between quarters    0.214 (0.226) −0.032 (0.108)
    P = 0.17 P = 0.54
Between years     −0.403 (0.217)
     P = 0.98
  1. a)Based on cases diagnosed during 1968–2011 inclusive
  2. b)\( \widehat{\upbeta} \) is the one-step estimate of β, the extra-Poisson variation, calculated as S/i(0) in the notation of Muirhead [42]
  3. c)SE is the standard error of \( \widehat{\upbeta} \) in the absence of extra-Poisson variation, calculated as 1/√i(0) in the notation of Muirhead [42]
  4. d)P-values have been calculated using 10000 simulations, assuming Poisson variation. All P-values are one-sided
  5. e)Cases with a diagnosis date of the 15th of the month have been excluded from the analyses between fortnights but have been included in the other analyses