Table 2 Associations of candidate SNPs with the risk of NIHL
Gene | SNP | Genotype | Control n (%) | Case n (%) | P-value | OR (95 % CI)a |
|---|---|---|---|---|---|---|
EYA4 | rs3777781 | TT | 137 (29.2) | 166 (35.2) | 1 | |
AT | 236 (50.3) | 235 (49.8) | 0.116 | 0.759 (0.539, 1.070) | ||
AA | 96 (20.5) | 71 (15.0) | 0.015 | 0.570 (0.363, 0.895) | ||
Ptrend | 0.019 | |||||
AT/AA | 332 (70.8) | 306 (64.8) | 0.047 | 0.721 (0.522, 0.996) | ||
rs212769 | GG | 354 (75.2) | 336 (71.0) | 1 | ||
AG | 112 (23.8) | 129 (27.3) | 0.062 | 1.395 (0.984,1.979) | ||
AA | 5 (1.1) | 8 (1.7) | 0.214 | 2.369 (0.608,9.234) | ||
Ptrend | 0.033 | |||||
AG/AA | 117 (24.8) | 137 (29.0) | 0.041 | 1.430 (1.014,2.016) | ||
GRHL2 | rs666026 | TT | 244 (51.9) | 222 (47.0) | 1 | |
GT | 186 (39.6) | 204 (43.2) | 0.118 | 1.287 (0.938,1.767) | ||
GG | 40 (8.5) | 46 (9.7) | 0.121 | 1.554 (0.891,2.71) | ||
Ptrend | 0.051 | |||||
GT/GG | 226 (48.1) | 250 (53.0) | 0.065 | 1.329 (0.983,1.798) | ||
DFNA5 | rs2521768 | TT | 289 (61.4) | 305 (64.6) | 0.158 | 1 |
CT | 155 (32.9) | 148 (31.4) | 0.249 | 0.825 (0.595,1.144) | ||
CC | 27 (5.7) | 19 (4.0) | 0.089 | 0.524 (0.249,1.104) | ||
Ptrend | 0.065 | |||||
CT/CC | 182 (38.6) | 167 (35.4) | 0.124 | 0.782 (0.571, 1.070) | ||
rs2521758 | TT | 450 (95.5) | 458 (97.0) | 1 | ||
GT | 20 (4.2) | 14 (3.0) | 0.078 | 0.474 (0.206,1.088) | ||
GG | 1 (0.2) | 0 (0.0) | 1.000 | |||
GT/GG | 21 (4.5) | 14 (3.0) | 0.052 | 0.441 (0.194,1.006) |