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Table 2 Associations of candidate SNPs with the risk of NIHL

From: Associations of genetic variations in EYA4, GRHL2 and DFNA5 with noise-induced hearing loss in Chinese population: a case- control study

Gene SNP Genotype Control n (%) Case n (%) P-value OR (95 % CI)a
EYA4 rs3777781 TT 137 (29.2) 166 (35.2)   1
  AT 236 (50.3) 235 (49.8) 0.116 0.759 (0.539, 1.070)
  AA 96 (20.5) 71 (15.0) 0.015 0.570 (0.363, 0.895)
  Ptrend    0.019  
  AT/AA 332 (70.8) 306 (64.8) 0.047 0.721 (0.522, 0.996)
rs212769 GG 354 (75.2) 336 (71.0)   1
  AG 112 (23.8) 129 (27.3) 0.062 1.395 (0.984,1.979)
  AA 5 (1.1) 8 (1.7) 0.214 2.369 (0.608,9.234)
  Ptrend    0.033  
  AG/AA 117 (24.8) 137 (29.0) 0.041 1.430 (1.014,2.016)
GRHL2 rs666026 TT 244 (51.9) 222 (47.0)   1
  GT 186 (39.6) 204 (43.2) 0.118 1.287 (0.938,1.767)
  GG 40 (8.5) 46 (9.7) 0.121 1.554 (0.891,2.71)
  Ptrend    0.051  
  GT/GG 226 (48.1) 250 (53.0) 0.065 1.329 (0.983,1.798)
DFNA5 rs2521768 TT 289 (61.4) 305 (64.6) 0.158 1
  CT 155 (32.9) 148 (31.4) 0.249 0.825 (0.595,1.144)
  CC 27 (5.7) 19 (4.0) 0.089 0.524 (0.249,1.104)
  Ptrend    0.065  
  CT/CC 182 (38.6) 167 (35.4) 0.124 0.782 (0.571, 1.070)
rs2521758 TT 450 (95.5) 458 (97.0)   1
  GT 20 (4.2) 14 (3.0) 0.078 0.474 (0.206,1.088)
  GG 1 (0.2) 0 (0.0) 1.000  
  GT/GG 21 (4.5) 14 (3.0) 0.052 0.441 (0.194,1.006)
  1. acalculated with logistic regression adjusted by age, CNE, smoking, drinking