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Table 3 Associations of liver histology with β-HCH and PCB118 at baselinea,b

From: Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study

  

β-HCH

PCB-118

 

n

Median (ng/g lipid)

OR (95 % CI)

p-value

Median (ng/g lipid)

OR (95 % CI)

p-value

Diagnosis

       

 Normal

38

13.4

Ref

 

15.2

Ref

 

 Steatosis

28

12.8

3.03 (0.46; 20.10)

0.250

9.42

0.49 (0.07; 3.46)

0.473

 NASH

31

11.9

0.33 (0.03; 3.73)

0.373

10.1

0.10 (0.01; 0.88)

0.038

Lobular Inflammation

       

 None

92

13.2

Ref

 

11.1

Ref

 

 <2 foci per 200x field

47

12.5

0.55 (0.11; 2.77)

0.468

9.14

0.16 (0.03; 0.81)

0.027

 2–4 foci per 200x field

10

8.93

0.02 (<0.01; 0.59)

0.022

5.55

0.01 (<0.01; 0.26)

0.005

Liver cell ballooning

       

 None

109

13.3

Ref

 

11.0

Ref

 

 Few balloon cells

36

12.0

0.16 (0.02; 1.09)

0.061

9.23

0.17 (0.03; 0.89)

0.036

 Many cells/prominent ballooning

4

8.65

0.35 (0.01; 23.27)

0.623

7.31

0.33 (0.00; 22.9)

0.606

Steatosisgrade

       

 <5 %

50

13.1

Ref

 

12.6

Ref

 

 5–33 %

59

13.5

1.09 (0.24; 4.83)

0.914

9.83

0.30 (0.06; 1.49)

0.141

 33–66 %

23

11.9

0.19 (0.02; 2.15)

0.180

9.15

0.11 (0.01; 0.98)

0.048

 >66 %

17

10.4

0.20 (0.02; 2.51)

0.213

9.14

0.14 (0.01; 1.44)

0.098

  1. aResults reported only for β-HCH and PCB118 because other POPs had no significant associations
  2. bConcentrations of β-HCH and PCB-118 (ng/g lipids) were log-transformed for the multinomial logistic regression analysis that was adjusted for age, BMI, sex and fasting insulin