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Table 1 Effect of colestimide on the individual congener concentrations of PCDDs, PCDFs, and dioxin-like PCBs in the blood of Yusho patients

From: Effect of colestimide on the concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dizenzofurans, and polychlorinated biphenyls in blood of Yusho patients

Congeners Concentration (pg/g lipid) p Values
Before the clinical trial After the clinical trial
Mean Median SD Minimum Maximum Mean Median SD Minimum Maximum
2,3,7,8-TetraCDD 1.8 1.7 0.9 0.5 4.0 2.0 1.8 1.2 0.5 4.7 0.083
1,2,3,7,8-PentaCDD 14 14 4.9 6.6 23 14 12 6.1 6.1 27 0.675
1,2,3,4,7,8-HexaCDD 3.1 3.0 1.7 1.0 7.1 3.3 3.2 1.7 1.0 6.9 0.053
1,2,3,6,7,8-HexaCDD 62 53 36 16 183 63 55 34 15 164 0.258
1,2,3,7,8,9-HexaCDD 5.5 4.5 5.2 2.1 29 5.7 3.9 6.0 1.0 31 0.770
1,2,3,4,6,7,8-HeptaCDD 55 47 25 21 113 52 43 27 20 143 0.137
OctaCDD 699 606 281 323 326 670 543 309 305 1610 0.118
Total PCDD 841 739 315 413 1525 811 688 346 382 1850 0.144
2,3,7,8-TetraCDF 2.8 2.7 1.3 0.5 5.5 2.7 2.6 1.4 0.5 5.8 0.427
1,2,3,7,8-PentaCDF 1.3 1.1 0.9 0.5 3.5 1.5 1.2 1.1 0.5 4.4 0.554
2,3,4,7,8-PentaCDF 241 191 158 48 636 242 205 158 49 613 0.732
1,2,3,4,7,8-HexaCDF 64 51 56 7.8 227 64 52 56 8.1 207 0.990
1,2,3,6,7,8-HexaCDF 26 21 19 6.2 86 26 22 19 5.2 74 0.534
2,3,4,6,7,8-HexaCDF 1.2 1.0 0.7 1.0 3.4 1.2 1.0 0.6 1.0 3.4 1.000
1,2,3,7,8,9-HexaCDF ND      ND      
1,2,3,4,6,7,8-HeptaCDF 2.2 1.0 1.5 1.0 6.5 2.3 1.0 1.8 1.0 7.8 0.820
1,2,3,4,7,8,9-HeptaCDF ND      ND      
OctaCDF ND      ND      
Total PCDF 342 280 229 71 963 344 292 230 71 890 0.732
33'4'4'-TriCB(#77) 6.9 5.0 3.7 5.0 16 8.9 7.5 4.3 5.0 20 0.016
344'5-TriCB(#81) 5.3 5.0 1.4 5.0 12 5.7 5.0 2.4 5.0 15 0.180
33'44'5-PentaCB(#126) 129 100 81 30 391 131 96 85 34 356 0.770
33'44'55'-HexaCB(169) 279 250 144 104 678 293 280 129 114 585 0.101
Total Non-ortho PCBs 420 382 178 183 906 439 406 166 196 789 0.078
233'44'-PentaCB(#105) 4454 3145 3555 1206 13788 4581 3236 3714 5.0 15228 0.501
2344'5-PentaCB(#114) 2800 2365 1688 5.0 7194 2997 2681 1699 5.0 6987 0.118
23'44'5-PentaCB(#118) 21718 16568 17601 5.0 75475 21050 15412 14335 4575 57260 0.990
2'344'5-PentaCB(#123) 304 228 273 5.0 1239 312 214 237 5.0 898 0.581
233'44'5-HexaCB(#156) 50472 32661 46375 13079 195017 51038 30741 43667 9528 180163 0.517
233'44'5'-HexaCB(#157) 13157 8088 13150 3390 53954 12747 7644 11520 2332 46994 0.990
23'44'55'-HexaCB(#167) 4834 4243 3373 5.0 16863 4610 4265 2422 985 10481 0.770
233'44'55'-HeptaCB(#189) 7385 5100 5888 1664 24429 7398 5397 5323 1730 22434 0.829
Total Mono-ortho PCBs 105125 83472 66740 40066 293077 104734 93659 59308 34746 267273 0.829
TEQ from PCDDs 24 24 7.9 11 43 24 24 9.2 11 42 0.809
TEQ from PCDFs 82 63 54 16 223 82 68 54 16 211 0.534
TEQ from PCDDs/PCDFs 106 83 60 27 265 107 87 61 28 249 0.790
TEQ from non-ortho PCBs 21 20 9.8 7.4 54 22 20 9.7 7.8 47 0.485
TEQ from mono-ortho PCBs 3.2 2.5 2.0 1.2 8.8 3.1 2.8 1.8 1.0 8.0 0.829
TEQ from dioxin-like PCBs 24 22 11 9.0 60 25 23 11 9.1 51 0.603
Total TEQ 130 120 65 42 303 132 117 65 43 283 0.869
  1. ND (less than the detection limit) values introduced to half values of the detection limit and calculated the TEQ concentrations
  2. SD standard deviation, CDD chlorinated dibenzo-p-dioxin, CDF chlorinated dibenzofuran