Table 1 Effect of colestimide on the individual congener concentrations of PCDDs, PCDFs, and dioxin-like PCBs in the blood of Yusho patients
Congeners | Concentration (pg/g lipid) | p Values | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Before the clinical trial | After the clinical trial | ||||||||||
Mean | Median | SD | Minimum | Maximum | Mean | Median | SD | Minimum | Maximum | ||
2,3,7,8-TetraCDD | 1.8 | 1.7 | 0.9 | 0.5 | 4.0 | 2.0 | 1.8 | 1.2 | 0.5 | 4.7 | 0.083 |
1,2,3,7,8-PentaCDD | 14 | 14 | 4.9 | 6.6 | 23 | 14 | 12 | 6.1 | 6.1 | 27 | 0.675 |
1,2,3,4,7,8-HexaCDD | 3.1 | 3.0 | 1.7 | 1.0 | 7.1 | 3.3 | 3.2 | 1.7 | 1.0 | 6.9 | 0.053 |
1,2,3,6,7,8-HexaCDD | 62 | 53 | 36 | 16 | 183 | 63 | 55 | 34 | 15 | 164 | 0.258 |
1,2,3,7,8,9-HexaCDD | 5.5 | 4.5 | 5.2 | 2.1 | 29 | 5.7 | 3.9 | 6.0 | 1.0 | 31 | 0.770 |
1,2,3,4,6,7,8-HeptaCDD | 55 | 47 | 25 | 21 | 113 | 52 | 43 | 27 | 20 | 143 | 0.137 |
OctaCDD | 699 | 606 | 281 | 323 | 326 | 670 | 543 | 309 | 305 | 1610 | 0.118 |
Total PCDD | 841 | 739 | 315 | 413 | 1525 | 811 | 688 | 346 | 382 | 1850 | 0.144 |
2,3,7,8-TetraCDF | 2.8 | 2.7 | 1.3 | 0.5 | 5.5 | 2.7 | 2.6 | 1.4 | 0.5 | 5.8 | 0.427 |
1,2,3,7,8-PentaCDF | 1.3 | 1.1 | 0.9 | 0.5 | 3.5 | 1.5 | 1.2 | 1.1 | 0.5 | 4.4 | 0.554 |
2,3,4,7,8-PentaCDF | 241 | 191 | 158 | 48 | 636 | 242 | 205 | 158 | 49 | 613 | 0.732 |
1,2,3,4,7,8-HexaCDF | 64 | 51 | 56 | 7.8 | 227 | 64 | 52 | 56 | 8.1 | 207 | 0.990 |
1,2,3,6,7,8-HexaCDF | 26 | 21 | 19 | 6.2 | 86 | 26 | 22 | 19 | 5.2 | 74 | 0.534 |
2,3,4,6,7,8-HexaCDF | 1.2 | 1.0 | 0.7 | 1.0 | 3.4 | 1.2 | 1.0 | 0.6 | 1.0 | 3.4 | 1.000 |
1,2,3,7,8,9-HexaCDF | ND | ND | |||||||||
1,2,3,4,6,7,8-HeptaCDF | 2.2 | 1.0 | 1.5 | 1.0 | 6.5 | 2.3 | 1.0 | 1.8 | 1.0 | 7.8 | 0.820 |
1,2,3,4,7,8,9-HeptaCDF | ND | ND | |||||||||
OctaCDF | ND | ND | |||||||||
Total PCDF | 342 | 280 | 229 | 71 | 963 | 344 | 292 | 230 | 71 | 890 | 0.732 |
33'4'4'-TriCB(#77) | 6.9 | 5.0 | 3.7 | 5.0 | 16 | 8.9 | 7.5 | 4.3 | 5.0 | 20 | 0.016 |
344'5-TriCB(#81) | 5.3 | 5.0 | 1.4 | 5.0 | 12 | 5.7 | 5.0 | 2.4 | 5.0 | 15 | 0.180 |
33'44'5-PentaCB(#126) | 129 | 100 | 81 | 30 | 391 | 131 | 96 | 85 | 34 | 356 | 0.770 |
33'44'55'-HexaCB(169) | 279 | 250 | 144 | 104 | 678 | 293 | 280 | 129 | 114 | 585 | 0.101 |
Total Non-ortho PCBs | 420 | 382 | 178 | 183 | 906 | 439 | 406 | 166 | 196 | 789 | 0.078 |
233'44'-PentaCB(#105) | 4454 | 3145 | 3555 | 1206 | 13788 | 4581 | 3236 | 3714 | 5.0 | 15228 | 0.501 |
2344'5-PentaCB(#114) | 2800 | 2365 | 1688 | 5.0 | 7194 | 2997 | 2681 | 1699 | 5.0 | 6987 | 0.118 |
23'44'5-PentaCB(#118) | 21718 | 16568 | 17601 | 5.0 | 75475 | 21050 | 15412 | 14335 | 4575 | 57260 | 0.990 |
2'344'5-PentaCB(#123) | 304 | 228 | 273 | 5.0 | 1239 | 312 | 214 | 237 | 5.0 | 898 | 0.581 |
233'44'5-HexaCB(#156) | 50472 | 32661 | 46375 | 13079 | 195017 | 51038 | 30741 | 43667 | 9528 | 180163 | 0.517 |
233'44'5'-HexaCB(#157) | 13157 | 8088 | 13150 | 3390 | 53954 | 12747 | 7644 | 11520 | 2332 | 46994 | 0.990 |
23'44'55'-HexaCB(#167) | 4834 | 4243 | 3373 | 5.0 | 16863 | 4610 | 4265 | 2422 | 985 | 10481 | 0.770 |
233'44'55'-HeptaCB(#189) | 7385 | 5100 | 5888 | 1664 | 24429 | 7398 | 5397 | 5323 | 1730 | 22434 | 0.829 |
Total Mono-ortho PCBs | 105125 | 83472 | 66740 | 40066 | 293077 | 104734 | 93659 | 59308 | 34746 | 267273 | 0.829 |
TEQ from PCDDs | 24 | 24 | 7.9 | 11 | 43 | 24 | 24 | 9.2 | 11 | 42 | 0.809 |
TEQ from PCDFs | 82 | 63 | 54 | 16 | 223 | 82 | 68 | 54 | 16 | 211 | 0.534 |
TEQ from PCDDs/PCDFs | 106 | 83 | 60 | 27 | 265 | 107 | 87 | 61 | 28 | 249 | 0.790 |
TEQ from non-ortho PCBs | 21 | 20 | 9.8 | 7.4 | 54 | 22 | 20 | 9.7 | 7.8 | 47 | 0.485 |
TEQ from mono-ortho PCBs | 3.2 | 2.5 | 2.0 | 1.2 | 8.8 | 3.1 | 2.8 | 1.8 | 1.0 | 8.0 | 0.829 |
TEQ from dioxin-like PCBs | 24 | 22 | 11 | 9.0 | 60 | 25 | 23 | 11 | 9.1 | 51 | 0.603 |
Total TEQ | 130 | 120 | 65 | 42 | 303 | 132 | 117 | 65 | 43 | 283 | 0.869 |