Element | Explanation | Example for perfluorooctanoic acid (PFOA) and birth weight in animals (adapted from [54]) | Example for perfluorooctanoic acid (PFOA) and birth weight in humans (adapted from [53]) |
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(P) Population | Condition or disease, characteristics/demographics of the participants. Which setting?, e.g., general population, occupational setting | Laboratory rodents exposed to PFOA in utero, assessed in early postnatal life | Humans that are studied during reproductive/developmental time period (before and/or during pregnancy or development). |
(E) Exposures | What are the exposures of interest? What types of chemical(s), what is the timing of exposure that will be considered? Which duration/frequency of exposure or timing of follow-up in relation to exposure? | Exposure to perfluorooctanoic acid (PFOA), CAS# 335-67-1, or its salts prior to mating, or during pregnancy | Exposure to perfluorooctanoic acid (PFOA), CAS# 335-67-1, or its salts during the time before pregnancy and/or during pregnancy for females or directly to foetuses |
(C) Comparator | Which exposure groups will be compared to each other (high versus low exposure) (exposure versus control)? | Exposed groups versus vehicle-treated or naïve controls | Humans exposed to lower levels of PFOA than the more highly exposed humans. |
(O) Outcome | Which outcomes will be included or covered? Consider adverse effects as well as potential adverse effects. | Body weight during first five days of postnatal development, total litter weight, measures of size such as body length | Effects on fetal growth, birth weight, and/or other measures of size such as length. |