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Table 4 Example descriptors that can be used to characterize confidence in the strength of the evidence between two factors (like exposure and adverse outcomes) within a data stream

From: A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals

Descriptor Explanation
High New research is unlikely to change the conclusions drawn from the currently available studies; conclusions are based on a set of studies in which chance, bias, confounding and other alternative explanations can reasonably be ruled out.
Medium New research could affect the interpretation of the findings. Conclusions are based on a set of studies in which chance, bias, confounding or other alternative explanations cannot reasonably be ruled out as explanations.
Low The available studies do not allow an inference regarding toxicity because of limitations such as inadequate sensitivity or relevance of the study designs.
Absent No studies available.