Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study

Kelly, Rachel S.; Kiviranta, Hannu; Bergdahl, Ingvar A.; Palli, Domenico; Johansson, Ann-Sofie; Botsivali, Maria; Vineis, Paolo; Vermeulen, Roel; Kyrtopoulos, Soterios A.; Chadeau-Hyam, Marc

doi:10.1186/s12940-017-0214-8

Environmental Health

Table 5 Association between log-transformed body burden of six PCB congeners, specified PCB functional groups, HCB and DDE, levels and NHL risk stratified by Subtype

From: Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study

Exposure	CLL (n = 42)						DLBCL (n = 45)
Exposure	OR	95% CI	p-value	OR^(adj)	95% CI	p-value	OR	95% CI	p-value	OR^(adj)	95% CI	p-value
PCB118	0.70	(0.31,1.58)	0.398	5.14	(0.56,47.08)	0.147	0.74	(0.27,2.04)	0.561	0.39	(0.06,2.68)	0.335
PCB138	0.63	(0.26,1.54)	0.309	1.33	(0.15,11.91)	0.801	0.37	(0.10,1.32)	0.126	0.33	(0.04,2.47)	0.281
PCB153	0.50	(0.16,1.52)	0.221	0.70	(0.06,7.77)	0.772	0.32	(0.08,1.26)	0.103	0.16	(0.01,1.84)	0.140
PCB156	0.57	(0.16,2.10)	0.402	1.47	(0.11,19.75)	0.773	0.25	(0.06,0.96)	0.044^*	0.01	(0,0.53)	0.023^*
PCB170	0.52	(0.16,1.66)	0.267	0.34	(0.03,3.61)	0.372	0.24	(0.06,1.02)	0.053	0.01	(0,0.47)	0.021^*
PCB180	0.49	(0.14,1.77)	0.278	0.27	(0.02,4.15)	0.351	0.23	(0.05,0.97)	0.045^*	0.01	(0,0.50)	0.020^*
HCB	0.42	(0.14,1.26)	0.121	1.12	(0.17,7.40)	0.905	0.90	(0.34,2.39)	0.834	0.41	(0.08,2.00)	0.271
DDE	0.83	(0.44,1.58)	0.578	1.99	(0.52,7.59)	0.313	0.88	(0.43,1.84)	0.743	1.17	(0.35,3.97)	0.796
Exposure	FL (n = 39)						MM (n = 76)
Exposure	OR	95% CI	p-value	OR^b(adj)	95% CI	p-value	OR	95% CI	p-value	OR^b(adj)	95% CI	p-value
PCB118	0.95	(0.41,2.21)	0.904	1.04	(0.34,3.13)	0.947	1.06	(0.55,2.07)	0.856	0.62	(0.23,1.63)	0.330
PCB138	0.91	(0.31,2.67)	0.865	1.17	(0.29,4.77)	0.822	0.74	(0.32,1.70)	0.474	0.45	(0.15,1.32)	0.145
PCB153	0.94	(0.29,3.04)	0.918	1.20	(0.27,5.31)	0.814	0.73	(0.29,1.85)	0.512	0.41	(0.12,1.42)	0.159
PCB156	0.99	(0.32,3.01)	0.979	1.12	(0.24,5.36)	0.885	0.77	(0.31,1.88)	0.561	0.47	(0.14,1.62)	0.234
PCB170	1.39	(0.43,4.51)	0.580	1.65	(0.33,8.24)	0.540	0.77	(0.30,2.00)	0.588	0.42	(0.11,1.66)	0.216
PCB180	1.43	(0.44,4.63)	0.553	1.52	(0.31,7.41)	0.605	0.90	(0.35,2.31)	0.834	0.56	(0.15,2.10)	0.392
HCB	0.82	(0.36,1.86)	0.633	0.83	(0.25,2.70)	0.752	0.70	(0.30,1.61)	0.394	0.31	(0.08,1.19)	0.089
DDE	0.77	(0.41,1.48)	0.437	0.93	(0.34,2.55)	0.885	0.66	(0.37,1.15)	0.142	0.52	(0.25,1.10)	0.086

Results for the four largest subtype groups were included
OR – conditional logistic regression accounting for matching factors
OR^(adj) – conditional logistic regression additionally adjusting for BMI, height, educational level, vegetables, dairy, protein, total fat, alcohol
^*Significant at the 95% confidence level; Matched case-control pairs with incomplete information on potential confounders were excluded from the adjusted analyses

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