Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit: a case control study

Wielsøe, Maria; Kern, Peder; Bonefeld-Jørgensen, Eva Cecilie

doi:10.1186/s12940-017-0269-6

Environmental Health

Table 3 Serum levels of lipophilic POPs (μg/kg lipid) in cases and controls in the two recruitment periods

From: Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit: a case control study

Parameters	2000–2003			2011–2014			p-value ^a	p-value ^b	p-value ^c
	Median serum levels			Median serum levels			all	cases	controls
	All	Cases	Controls	All	Cases	Controls
∑PCB	1995.18	2048.80	1985.94	798.50	1014.90	577.40	<0.001	0.266	<0.001
∑PCB Grp1	173.75	172.07	173.75	76.00	93.35	53.50	<0.001	0.280	<0.001
∑PCB Grp2	755.42	696.47	767.50	220.80	290.65	173.10	<0.001	0.097	<0.001
∑PCB Grp3	1062.77	1106.39	1062.68	515.00	628.50	354.00	0.002	0.400	0.001
∑DL-PCB	173.86	149.32	182.90	60.00	70.05	49.90	<0.001	0.044	<0.001
PCB99	78.65	70.28	81.36	31.00	38.50	23.00	<0.001	0.019	<0.001
PCB101	7.27	5.44	9.16	3.00	3.00	3.00	<0.001	<0.001	0.012
PCB105	19.17	16.59	22.29	5.60	7.95	5.00	<0.001	0.013	<0.001
PCB118	99.76	99.61	99.76	34.00	48.50	32.00	<0.001	0.019	<0.001
PCB138	378.43	357.47	385.24	110.00	165.00	79.00	<0.001	0.041	<0.001
PCB153	585.14	636.81	583.66	270.00	355.00	200.00	0.002	0.399	0.001
PCB156	50.00	46.13	56.63	15.00	22.50	14.00	<0.001	0.256	<0.001
PCB170	120.00	113.62	128.75	51.00	65.50	36.00	0.005	0.676	0.001
PCB180	353.61	349.44	353.61	170.00	195.00	120.00	0.007	0.591	0.002
PCB183	36.94	39.83	36.72	13.00	18.50	12.00	<0.001	0.061	<0.001
PCB187	162.05	166.19	161.95	73.00	88.00	51.00	<0.001	0.061	<0.001
∑OCP	2303.45	2531.58	2127.71	1013.00	1539.50	847.00	<0.001	0.062	<0.001
Cis-Nonachlor	79.29	94.30	77.84	40.00	46.50	29.00	<0.001	0.165	0.001
Trans-Nonachlor	405.42	509.67	343.07	200.00	270.00	150.00	0.011	0.606	0.004
HCB	257.01	265.04	257.01	110.00	130.00	85.00	<0.001	0.008	<0.001
Mirex	37.50	33.52	40.82	19.00	21.00	13.00	0.009	0.926	0.010
Oxychlordane	235.94	301.72	213.64	110.00	115.00	82.00	0.005	0.429	0.003
p,p’DDE	1129.46	1288.21	1039.19	550.00	680.00	420.00	<0.001	0.018	<0.001
p,p’DDT	29.51	31.54	25.00	9.50	10.00	8.00	<0.001	<0.001	<0.001
βHCH	40.63	42.26	38.96	15.00	17.50	12.00	<0.001	0.004	<0.001

The differences between the two recruitment periods were tested with independent samples t-test. ^aThe p-value form independent samples t-test on ln-transformed variables between all the participants; ^bThe p-value from independent samples t-test on ln-transformed variables between the cases; ^cThe p-value from independent samples t-test on ln-transformed variables between the controls; Bold text: significant finding; ∑PCB: PCB 99, 101, 105, 118, 128, 138, 153, 156, 170, 180, 183, 187; ∑PCB group 1 (estrogenic PCBs): PCB 101, 187; ∑PCB group 2 (anti-estrogenic and dioxin-like PCBs): PCB 105, 118, 128, 138, 156, 170; ∑PCB group 3 (CYP1A1 and CYP2B inducing PCBs): PCB 99, 153, 180, 183; ∑DL-PCBs (dioxin-like PCBs): PCB 105, 118, 156; ∑OCP: p,p′-DDT, p,p′-DDE, mirex, β-HCH, HCB, cis- and trans-nonachlor, and oxychlordane. The serum concentration of the lipophilic POPs was measured in μg/kg lipid

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