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Table 8 Sensitivity analyses for the associations of respiratory disease incidence with NO2 in fully adjusted models

From: Long-term exposure to ambient ultrafine particles and respiratory disease incidence in in Toronto, Canada: a cohort study

Sensitivity analysis COPD Asthma Lung cancer a
HR 95% CI HR 95% CI HR 95% CI
Results from the Main Analyses (Table 4) 1.11 1.07 1.15 1.03 1.02 1.05 1.07 1.04 1.10
Two different time windows of exposure
 1 year before event 1.11 1.07 1.15 1.05 1.04 1.06 NA NA NA
 2 year before event 1.11 1.07 1.15 1.05 1.04 1.06 NA NA NA
Two different lags in the exposure
 0-year lag b NA NA NA NA NA NA 1.10 1.08 1.13
 2-year lag c NA NA NA NA NA NA 1.10 1.07 1.12
 Restricted to subjects who lived at their baseline addresses for ≥5 years prior to cohort entry 1.11 1.07 1.15 1.05 1.04 1.06 1.07 1.04 1.10
 Adjusted for a linear term for time 1.11 1.07 1.15 1.03 1.02 1.05 1.07 1.04 1.10
Adjusted for the distance to roadways 1.06 1.03 1.09 1.02 1.01 1.03 1.04 1.01 1.07
Indirect adjustment (with HRs directly calculated from the CCHS cohort)
  + Smoking only 1.08 1.03 1.13 1.03 1.02 1.04 1.02 0.97 1.08
  + Smoking and BMI 1.09 1.04 1.15 1.04 1.02 1.05 1.01 0.95 1.07
  1. aThe cohort was followed up from April 1, 2001 to December 31, 2012
  2. bThe cohort was followed up from April 1, 1996 to December 31, 2012
  3. cThe cohort was followed up from April 1, 1998 to December 31, 2012. All models are stratified by age and sex, include a frailty term for neighborhoods, and are adjusted for neighborhood-level covariates