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Table 2 RR and CIsb for ever versus never use of OC insecticides, for all cancer sites±

From: A prospective study of cancer risk among Agricultural Health Study farm spouses associated with personal use of organochlorine insecticides

  N total Any OCa Chlordane DDT Lindane Aldrin Heptachlor Toxaphene Dieldrin
N exposed RR 95% CI N exposed RR 95% CI N exposed RR 95% CI N exposed RR 95% CI N exposed RR 95% CI N exposed RR 95% CI N exposed RR 95% CI N exposed RR 95% CI
All Cancer Sitesc 3,204 287 0.96 0.85–1.08 160 0.99 0.84–1.16 158 0.98 0.83–1.15 46 0.91 0.68–1.22 41 1.12 0.82–1.53 36 1.06 0.76–1.48 29 1.05 0.73–1.52 17 1.02 0.63–1.65
Solid tumors
  Bladder 103 4 0.64 0.23–1.77 1 _ _ 3 0.83 0.26–2.67 1 _ _ 0 _ _ 0 _ _ 1 _ _ 0 _ _
  Colon 236 28 1.19 0.80–1.75 18 1.42 0.87–2.32 16 1.17 0.70–1.95 3 0.79 0.25–2.49 6 1.73 0.76–3.91 4 1.24 0.46–3.36 3 1.31 0.42–4.12 4 2.41 0.89–6.53
  Glioma 44 11 3.52 1.72–7.21 4 1.81 0.64–5.12 2 _ _ 3 4.45 1.36–14.55 1 _ _ 2 _ _ 2 _ _ 0 _ _
  Kidney 71 6 0.89 0.38–2.08 3 0.85 0.26–2.72 5 1.41 0.56–3.57 0 _ _ 1 _ _ 0 _ _ 2 _ _ 0 _ _
  Lung 203 15 0.70 0.41–1.20 10 0.90 0.47–1.71 10 0.84 0.44–1.59 2 _ _ 2 _ _ 1 _ _ 5 2.13 0.87–5.21 2 _ _
  Melanoma (cutaneous) 145 12 1.08 0.59–1.97 4 0.63 0.23–1.72 5 0.88 0.36–2.18 2 _ _ 3 2.20 0.69–7.02 3 2.40 0.75–7.64 1 _ _ 1 _ _
  Pancreas 55 7 1.33 0.59–2.97 3 1.03 0.32–3.34 1 _ _ 3 3.70 1.15–12.0 1 _ _ 1 _ _ 0 _ _ 0 _ _
  Rectum 69 8 1.27 0.60–2.70 6 1.80 0.77–4.21 6 1.79 0.76–4.22 0 _ _ 1 _ _ 1 _ _ 1 _ _ 0 _ _
  Stomach 26 5 2.61 0.96–7.11 1 _ _ 3 2.64 0.76–9.15 1 _ _ 1 _ _ 0 _ _ 0 _ _ 0 _ _
  Thyroid 54 5 0.66 0.26–1.63 4 0.97 0.36–2.67 1 _ _ 0 _ _ 1 _ _ 1 _ _ 0 _ _ 0 _ _
Lymphohematopoietic malignancies
  NHL 233 28 1.23 0.82–1.83 17 1.35 0.82–2.22 17 1.35 0.81–2.22 6 1.60 0.71–3.60 1 _ _ 3 1.03 0.33–3.24 3 1.49 0.48–4.68 0 _ _
  Multiple Myeloma 42 8 2.01 0.91–4.42 6 2.71 1.12–6.55 4 1.75 0.61–5.01 1 _ _ 0 _ _ 1 _ _ 1 _ _ 0 _ _
  Myeloid Leukemia 34 4 1.26 0.44–3.65 3 1.82 0.55–6.09 3 1.66 0.49–5.56 0 _ _ 0 _ _ 1 _ _ 0 _ _ 0 _ _
Female specific sites
  Breast 1,214 99 0.89 0.72–1.09 56 0.93 0.71–1.22 52 0.89 0.67–1.18 17 0.88 0.54–1.42 11 0.88 0.48–1.59 11 0.93 0.51–1.68 5 0.49 0.20–1.18 6 1.06 0.48–2.38
  ER + PR+ 736 64 0.94 0.73–1.23 36 0.98 0.70–1.37 33 0.93 0.65–1.33 9 0.75 0.39–1.45 8 1.00 0.50–2.02 8 1.05 0.52–2.11 2 _ _ 3 0.83 0.27–2.60
  ER-PR- 202 15 0.82 0.48–1.40 9 0.90 0.46–1.76 7 0.76 0.36–1.63 4 1.22 0.45–3.30 2 _ _ 2 _ _ 1 _ _ 3 3.55 1.12–11.18
  ER + PR- 125 8 0.65 0.32–1.35 5 0.78 0.32–1.92 4 0.61 0.22–1.67 2 _ _ 0 _ _ 0 _ _ 1 _ _ 0 _ _
  Ovarian 106 9 0.65 0.30–1.61 7 1.05 0.40–2.89 5 0.77 0.20–2.46 2 _ _ 2 _ _ 2 _ _ 1 _ _ 1 _ _
  Uterine 276 20 0.83 0.50–1.32 10 0.80 0.40–1.50 10 0.82 0.42–1.56 2 _ _ 4 1.50 0.60–4.06 3 1.12 0.40–3.51 2 _ _ 1 _ _
  1. Significant Findings are listed in boldface
  2. AHS Agricultural Health Study, RR relative risks, OC organochlorines, ER estrogen receptor, PR progesterone receptor
  3. ± n ≥ 3 exposed cases
  4. aEver use of any of the seven OC insecticides
  5. bAdjusted for age, education, state of residence, pack-years smoked, and alcohol consumption
  6. cInclusive of all reported cancer sites