Table 2 Associations between cumulative average radon and breast cancer risk in NHSII from 1989 to 2013 (n = 112,639)
From: Environmental radon exposure and breast cancer risk in the Nurses’ Health Study II
Outcomea | Cases (n) | Person-years (n) | Basicb HR (95% CI) | Fully adjustedc HR (95% CI) |
|---|---|---|---|---|
Invasive breast cancer | ||||
Radon quintile 1 | 803 | 496,494 | Referent | Referent |
Radon quintile 2 | 810 | 503,957 | 1.03 (0.93, 1.13) | 1.02 (0.92, 1.14) |
Radon quintile 3 | 797 | 503,121 | 1.01 (0.92, 1.12) | 1.02 (0.90, 1.14) |
Radon quintile 4 | 745 | 499,349 | 0.94 (0.85, 1.04) | 0.96 (0.85, 1.08) |
Radon quintile 5 | 811 | 499,773 | 1.02 (0.93, 1.13) | 1.06 (0.94, 1.21) |
p for trend | 0.96 | 0.30 | ||
Continuous radon (per IQR increase)d | 3966 | 2,502,695 | 0.99 (0.96, 1.02) | 1.01 (0.97, 1.04) |
ER+ | ||||
Radon quintile 1 | 490 | 496,797 | Referent | Referent |
Radon quintile 2 | 471 | 504,288 | 0.98 (0.87, 1.12) | 0.99 (0.87, 1.14) |
Radon quintile 3 | 498 | 503,420 | 1.04 (0.92, 1.18) | 1.07 (0.91, 1.24) |
Radon quintile 4 | 439 | 499,621 | 0.91 (0.80, 1.03) | 0.96 (0.82, 1.12) |
Radon quintile 5 | 475 | 500,089 | 0.98 (0.86, 1.11) | 1.05 (0.89, 1.23) |
p for trend | 0.53 | 0.66 | ||
Continuous radon (per IQR increase)d | 2373 | 2,504,215 | 0.99 (0.95, 1.03) | 1.01 (0.96, 1.05) |
ER- | ||||
Radon quintile 1 | 101 | 497,123 | Referent | Referent |
Radon quintile 2 | 112 | 504,612 | 1.11 (0.85, 1.46) | 1.13 (0.84, 1.51) |
Radon quintile 3 | 125 | 503,741 | 1.24 (0.96, 1.62) | 1.27 (0.92, 1.74) |
Radon quintile 4 | 114 | 499,939 | 1.14 (0.87, 1.49) | 1.17 (0.84, 1.62) |
Radon quintile 5 | 133 | 500,402 | 1.32 (1.02, 1.72) | 1.34 (0.97, 1.86) |
p for trend | 0.06 | 0.15 | ||
Continuous radon (per IQR increase)d | 585 | 2,505,817 | 1.05 (0.97, 1.13) | 1.03 (0.95, 1.12) |
ER+/PR+ | ||||
Radon quintile 1 | 417 | 496,859 | Referent | Referent |
Radon quintile 2 | 420 | 504,332 | 1.03 (0.90, 1.18) | 1.06 (0.91, 1.23) |
Radon quintile 3 | 441 | 503,469 | 1.09 (0.95, 1.24) | 1.13 (0.96, 1.33) |
Radon quintile 4 | 384 | 499,675 | 0.94 (0.81, 1.08) | 1.01 (0.85, 1.19) |
Radon quintile 5 | 412 | 500,148 | 1.00 (0.87, 1.15) | 1.10 (0.92, 1.30) |
p for trend | 0.61 | 0.60 | ||
Continuous radon (per IQR increase)d | 2074 | 2,504,483 | 0.99 (0.95, 1.04) | 1.01 (0.97, 1.06) |
ER−/PR- | ||||
Radon quintile 1 | 89 | 497,137 | Referent | Referent |
Radon quintile 2 | 93 | 504,633 | 1.05 (0.79, 1.41) | 1.07 (0.78, 1.46) |
Radon quintile 3 | 104 | 503,763 | 1.18 (0.89, 1.57) | 1.19 (0.85, 1.68) |
Radon quintile 4 | 104 | 499,946 | 1.19 (0.89, 1.58) | 1.20 (0.85, 1.69) |
Radon quintile 5 | 123 | 500,409 | 1.41 (1.07, 1.85) | 1.38 (0.97, 1.96) |
p for trend | 0.01 | 0.05 | ||
Continuous radon (per IQR increase)d | 513 | 2,505,889 | 1.08 (0.99, 1.16) | 1.05 (0.96, 1.15) |
ER+/PR- | ||||
Radon quintile 1 | 70 | 497,167 | Referent | Referent |
Radon quintile 2 | 47 | 504,679 | 0.69 (0.48, 1.00) | 0.62 (0.41, 0.93) |
Radon quintile 3 | 53 | 503,818 | 0.77 (0.54, 1.11) | 0.66 (0.42, 1.02) |
Radon quintile 4 | 53 | 499,984 | 0.76 (0.53, 1.09) | 0.67 (0.43, 1.04) |
Radon quintile 5 | 62 | 500,458 | 0.87 (0.61, 1.22) | 0.75 (0.48, 1.18) |
p for trend | 0.88 | 1.00 | ||
Continuous radon (per IQR increase)d | 285 | 2,506,105 | 0.97 (0.87, 1.09) | 0.98 (0.86, 1.11) |
ER−/PR−/HER2- | ||||
Radon quintile 1 | 49 | 497,173 | Referent | Referent |
Radon quintile 2 | 53 | 504,676 | 1.09 (0.74, 1.60) | 1.09 (0.71, 1.67) |
Radon quintile 3 | 52 | 503,820 | 1.07 (0.72, 1.58) | 1.06 (0.67, 1.68) |
Radon quintile 4 | 61 | 499,980 | 1.25 (0.86, 1.83) | 1.24 (0.78, 1.97) |
Radon quintile 5 | 78 | 500,452 | 1.61 (1.12, 2.31) | 1.52 (0.96, 2.41) |
p for trend | 0.003 | 0.02 | ||
Continuous radon (per IQR increase)d | 293 | 2,506,101 | 1.12 (1.01, 1.24) | 1.09 (0.97, 1.23) |