Polychlorinated biphenyls and depression: cross-sectional and longitudinal investigation of a dopamine-related Neurochemical path in the German HELPcB surveillance program

Table 6 Results of the mediation analyses of dlPCB body burden and depressive symptoms through HVA/crea using MEDIATE macro for SPSS [30]; controlled for age, albumin and traumatic experience

	Coefficient	SE	t	p
Total effect model (DV = depressive symptoms_t2)
dlPCB	.80	.31	2.56	.02
Covariates
Age	−.06	.04	−1.56	.07
Albumin	−.14	.19	−.72	.24
Traumatic experience	1.75	1.36	1.29	.10
Depressive symptoms_t1	.74	.09	8.62	<.001
Model fit
R²	.63			<.001
F	27.86
Effect of IV on HVA (mediator)
dlPCB	−1.40	.67	−2.10	.02
Effect of IV and mediator on depressive symptoms_t2
HVA/crea	−.12	.05	−2.41	.01
dlPCB	.63	.31	2.03	.03
Model fit
R²	.65			<.001
F	25.53
Homogeneity of regression (HPCB*HVA)
R²	.002			.27
F	0.39

Note: DV dependent variable, IV independent variable, t1 measurement occasion 1, t2 measurement occasion 2, dlPCBs dioxine-like polychlorinated biphenyls; HVA = homovanillic acid / creatinine, R ² explained variance, F F-value, SE standard error, t t-value, p p-value (significance)

ISSN: 1476-069X