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Table 4 Statistical analysis of the fatigue scores – adjusted mean changes from baseline and difference from placebo on day 15

From: Efficacy of N,N‘bis-(2-mercaptoethyl) isophthalamide on mercury intoxication: a randomized controlled trial

Adjusted change from baseline   Difference from Placebo  
Treatment N Adj.meana 95%-CIb Adj.meana 95%-CIb p-value
Physical fatigue score
 NBMI 100 mg 13 −3.769 [−5.343;-2.195] −1.353 [−3.433; 0.728] .2019
 NBMI 300 mg 11 −4.454 [−6.049;-3.042] −2.129 [−4.156;-0.102] .0396*
 Placebo 12 −2.417 [−3.777;-1.057]   
Mental fatigue score
 NBMI 100 mg 13 −2.000 [−3.048;-0.952] −1.083 [− 2.432; 0.266] .1152
 NBMI 300 mg 11 −2.182 [−3.335;-1.029] −1.265 [−2.698; 0.167] .0833
 Placebo 12 −0.917 [−1.767;-0.067]   
  1. The asterisk indicates a statistical difference to the placebo group with p < 0.05
  2. aAdjusted mean score reduction after fitting the daily measured fatigue scores in a Mixed Model of Repeated Measurements
  3. b95%-Confidence interval