Efficacy of N,N‘bis-(2-mercaptoethyl) isophthalamide on mercury intoxication: a randomized controlled trial

Table 4 Statistical analysis of the fatigue scores – adjusted mean changes from baseline and difference from placebo on day 15

Adjusted change from baseline				Difference from Placebo
Treatment	N	Adj.mean^a	95%-CI^b	Adj.mean^a	95%-CI^b	p-value
Physical fatigue score
NBMI 100 mg	13	−3.769	[−5.343;-2.195]	−1.353	[−3.433; 0.728]	.2019
NBMI 300 mg	11	−4.454	[−6.049;-3.042]	−2.129	[−4.156;-0.102]	.0396*
Placebo	12	−2.417	[−3.777;-1.057]	–
Mental fatigue score
NBMI 100 mg	13	−2.000	[−3.048;-0.952]	−1.083	[− 2.432; 0.266]	.1152
NBMI 300 mg	11	−2.182	[−3.335;-1.029]	−1.265	[−2.698; 0.167]	.0833
Placebo	12	−0.917	[−1.767;-0.067]	–

The asterisk indicates a statistical difference to the placebo group with p < 0.05
^aAdjusted mean score reduction after fitting the daily measured fatigue scores in a Mixed Model of Repeated Measurements
^b95%-Confidence interval

ISSN: 1476-069X