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Table 2 Associations of selected allergic and respiratory outcomes at age 5 years in relation to weighted road density within a 50 m radius of home adjusted for potential confounders stratified by fish oil supplementation

From: Childhood fish oil supplementation modifies associations between traffic related air pollution and allergic sensitisation

Total IgE

No fish oil supplementation

Fish oil supplementation

p-value for interaction

N

Mean difference

95% CI

p-value

N

Mean difference

95% CI

p-value

 

Total IgE (kU/L)

165

−0.023

−0.29−0.34

0.760

161

−0.18

−0.34−0.20

0.785

0.291

Questionnaire variables

 

RR

   

RR

   

 Doctor diagnosed asthma

186

0.91

0.58–1.43

0.689

186

1.18

0.82–1.71

0.370

0.384

 Ever had doctor diagnosed asthma

186

0.91

0.63–1.29

0.556

186

1.10

0.84–1.44

0.746

0.423

 Wheeze in the last 12 months

186

1.18

0.81–1.72

0.387

186

1.05

0.79–1.39

0.724

0.664

 Wheeze in the last 12 months & asthma

186

1.08

0.60–1.95

0.798

186

0.90

0.59–1.38

0.641

0.770

 Cough more than 4 times in the last 12 months

186

1.14

0.81–1.59

0.459

186

1.20

0.95–1.53

0.132

0.794

 Doctor diagnosed Eczema

186

1.13

0.78–1.65

0.514

186

1.43

1.10–1.87

0.007

0.631

 Eczema in the last 12 months

185

1.46

1.01–2.11

0.043

186

1.34

0.96–1.87

0.085

0.882

 Doctor diagnosed allergic rhinitis

186

1.27

0.61–2.64

0.528

186

3.44

1.82–6.47

0.000

0.969

Skin prick tests

 Any of 11 inhalant and food allergens

181

1.34

1.00–1.80

0.054

186

0.90

0.67–1.21

0.493

0.042

 Inhalant allergen

181

1.40

1.04–1.89

0.029

186

0.91

0.67–1.23

0.544

0.027

 Ingested allergen

181

0.51

0.10–2.63

0.424

186

1.28

0.55–2.99

0.571

0.695

 House dust mite (HDM)

181

1.74

1.22–2.48

0.002

186

1.03

0.76–1.41

0.840

0.015

 Alternaria tenuis

181

0.27

0.11–0.64

0.003

186

0.96

0.51–1.82

0.906

0.567

 Grass mix

181

1.34

0.71–2.55

0.368

186

1.04

0.56–1.92

0.910

0.963

 Rye Grass

181

1.33

0.70–2.53

0.382

185

1.08

0.66–1.78

0.761

0.906

HDM-specific cytokines

 IL-5 (> 10 pg/ml)

139

1.83

1.21–2.76

0.004

139

0.65

0.38–1.11

0.117

0.003

 IL-10 (> 10 pg/ml)

131

1

0.83–1.22

0.969

133

0.98

0.83–1.16

0.817

0.981

  1. All models are adjusted for sex, father’s education, mother’s education, environmental tobacco smoke exposure, breastfed to 6 months, any dog owned by 5 or 8 years, any cat owned by 5 or 8 years, maternal smoking in pregnancy, gas cooking at home
  2. Interaction term of fish oil supplementation with weighted road density was added as a separate term into a Poisson model
  3. Mean difference, Relative Risks (RRs) and 95% confidence intervals (95% CI) represent increase in risk per unit increase in weighted road density, representing 100 m local road or 33.3 m of motorway within 50 m of the home. N = number of children
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Environmental Health

ISSN: 1476-069X