Occupational exposure to asphalt mixture during road paving is related to increased mitochondria DNA copy number: a cross-sectional study

Table 5 Associations between changes (Δ) in PAH metabolites and post-working relative mtDNAcn / TL among asphalt workers; and ΔmtDNAcn / ΔTL in the repeated-measures analysis

Study population	ΔPAH metabolites	Post-working relative mtDNAcn		Post-working relative TL
Study population	ΔPAH metabolites	β (95%CI)	p^a	β (95%CI)	p^a
All asphalt workers	Δln(1-OH-PYR)	0.035 (−0.028, 0.098)	0.28	0.067 (−0.0038, 0.14)	0.064
(N = 138)	Δln(2-OH-PH)	0.048 (−0.015, 0.11)	0.14	0.075 (0.0046, 0.15)	0.037
		Δ mtDNAcn		Δ TL
		β (95%CI)	p^b	β (95%CI)	p^b
Repeated-measures analysis	Δln(1-OH-PYR)	−0.078 (− 0.14, − 0.016)	0.015	−0.064 (− 0.16, 0.028)	0.17
(N = 31)	Δln(2-OH-PH)	−0.057 (− 0.12, 0.0073)	0.080	− 0.048 (− 0.15, 0.049)	0.32

^aP values were derived from general linear model with age, BMI, smoking and snus states, cigarette pack-year, investigation season, and occupational groups as adjustments
^bP values were derived from linear mixed model with occupational groups and pre-working mtDNAcn or TL as adjustments

ISSN: 1476-069X