PFAS Serum Concentration | ER+ or PR+ (n = 1601) | ER- and PR- (n = 965) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
# cases | Crude Odds Ratio (OR) b | Adjusted Odds Ratio (OR) d | # cases | Crude Odds Ratio (OR) b | Adjusted Odds Ratio (OR) e | |||||
OR (95% CI)b | p-valuec | OR (95% CI) d | p-valuec | OR (95% CI)b | p-value c | OR (95% CI)e | p-valuec | |||
PFOA | ||||||||||
 Low | 266 | 1.00 | 0.50 | 1.00 | 0.71 | 43 | 1.00 | 0.38 | 1.00 | 0.39 |
 Medium | 247 | 0.923 (0.723, 1.178) | 0.918 (0.707, 1.191) | 35 | 0.824 (0.505, 1.346) | 0.846 (0.510, 1.403) | ||||
 High | 230 | 0.917 (0.711, 1.182) | 0.952 (0.725, 1.251) | 29 | 0.800 (0.474, 1.348) | 0.792 (0.460, 1.365) | ||||
 log [PFOA, ng/mL] | 743 | 0.781 (0.529, 1.151) | 0.21 | 0.779 (0.513, 1.183) | 0.24 | 107 | 0.523 (0.246, 1.111) | 0.09 | 0.528 (0.239, 1.165) | 0.11 |
PFNA | ||||||||||
 Low | 233 | 1.00 | 0.57 | 1.00 | 0.76 | 33 | 1.00 | 0.43 | 1.00 | 0.51 |
 Medium | 250 | 1.112 (0.868, 1.426) | 1.034 (0.789, 1.354) | 34 | 1.107 (0.659, 1.859) | 1.002 (0.583, 1.720) | ||||
 High | 234 | 1.076 (0.835, 1.387) | 0.959 (0.724, 1.270) | 36 | 1.231 (0.734, 2.064) | 1.186 (0.690, 2.039) | ||||
 log [PFNA, ng/mL] | 717 f | 1.096 (0.779, 1.543) | 0.60 | 0.924 (0.634, 1.346) | 0.68 | 103f | 0.783 (0.416, 1.475) | 0.45 | 0.701 (0.357, 1.375) | 0.30 |
PFUnDA | ||||||||||
 Low | 249 | 1.00 | 0.38 | 1.00 | 0.22 | 43 | 1.00 | 0.03 | 1.00 | 0.05 |
 Medium | 274 | 1.116 (0.876, 1.422) | 1.125 (0.866, 1.461) | 41 | 0.947 (0.591, 1.518) | 1.007 (0.614, 1.651) | ||||
 High | 220 | 0.889 (0.689, 1.146) | 0.838 (0.636, 1.106) | 23 | 0.522 (0.298, 0.912) | 0.550 (0.307, 0.985) | ||||
 log [PFUnDA, ng/mL] | 743 | 0.922 (0.710, 1.196) | 0.54 | 0.892 (0.671, 1.185) | 0.43 | 107 | 0.661 (0.386, 1.133) | 0.13 | 0.665 (0.375, 1.179) | 0.16 |
PFHxS | ||||||||||
 Low | 287 | 1.00 | 0.10 | 1.00 | 0.25 | 54 | 1.00 | 0.02 | 1.00 | 0.03 |
 Medium | 219 | 0.763 (0.594, 0.980) | 0.830 (0.635, 1.084) | 28 | 0.582 (0.352, 0.962) | 0.587 (0.350, 0.985) | ||||
 High | 237 | 0.812 (0.629, 1.048) | 0.855 (0.651, 1.122) | 25 | 0.558 (0.326, 0.954) | 0.567 (0.326, 0.985) | ||||
 log [PFHxS, ng/mL] | 743 | 0.874 (0.640, 1.193) | 0.40 | 0.915 (0.655, 1.279) | 0.60 | 107 | 0.449 (0.250, 0.807) | 0.01 | 0.446 (0.243, 0.821) | 0.01 |
PFOS | ||||||||||
 Low | 250 | 1.00 | 0.83 | 1.00 | 0.81 | 47 | 1.00 | 0.09 | 1.00 | 0.06 |
 Medium | 247 | 1.020 (0.796, 1.305) | 0.937 (0.721, 1.218) | 32 | 0.697 (0.427, 1.139) | 0.628 (0.378, 1.041) | ||||
 High | 246 | 1.029 (0.798, 1.327) | 0.967 (0.737, 1.270) | 28 | 0.652 (0.387, 1.100) | 0.615 (0.357, 1.059) | ||||
 log [PFOS, ng/mL] | 743 | 1.177 (0.852, 1.626) | 0.32 | 1.054 (0.744, 1.493) | 0.77 | 107 | 0.645 (0.375, 1.109) | 0.11 | 0.573 (0.323, 1.016) | 0.06 |
MeFOSAA | ||||||||||
 Low | 289 | 1.00 | 0.08 | 1.00 | 0.23 | 36 | 1.00 | 0.91 | 1.00 | 0.89 |
 Medium | 228 | 0.802 (0.628, 1.023) | 0.855 (0.660, 1.109) | 39 | 1.106 (0.675, 1.814) | 1.124 (0.674, 1.877) | ||||
 High | 226 | 0.806 (0.630, 1.030) | 0.854 (0.655, 1.113) | 32 | 0.968 (0.575, 1.630) | 0.960 (0.557, 1.654) | ||||
 log [MeFOSAA, ng/mL] | 743 | 0.864 (0.699, 1.067) | 0.18 | 0.932 (0.740, 1.173) | 0.55 | 107 | 0.983 (0.631, 1.531) | 0.94 | 0.996 (0.628, 1.578) | 0.98 |