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Table 9 Effects of glyphosate or Roundup Bioflow exposure on hormones in female (mean ± SEM)

From: The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

 

6 week cohort

13-week cohort

Control

Glyphosate

Roundup

Control

Glyphosate

Roundup

Serum Hormones

 No. of females examined

8 (8)

8 (8)

8 (8)

10 (10)

10 (10)

10 (10)

 TT (ng/ml)

0.66 ± 0.064

0.75 ± 0.12

0.68 ± 0.11a

0.51 ± 0.06

0.72 ± 0.10

0.72 ± 0.07b *

 fT (pg/ml)

6.49 ± 1.00c

6.74 ± 1.89d

7.70 ± 1.35a

9.18 ± 2.49

12.04 ± 1.25

12.52 ± 1.76b

 DHT (pg/ml)

294.28 ± 50.40

328.34 ± 51.93a

488.94 ± 114.68a

382.93 ± 52.14

460.09 ± 60.06

268.84 ± 45.56b

 SHBG (ng/ml)

864.82 ± 30.24

952.75 ± 54.98

903.07 ± 29.61

968.27 ± 21.39

993.44 ± 32.79

964.81 ± 27.20

 E2 (pg/ml)g

14.95 ± 7.24

32.24 ± 8.77

66.96 ± 25.17

18.08 ± 8.49

28.48 ± 13.71

43.91 ± 9.92

Plasma Hormones

 No. of females examined

7 (8)

7 (8)

6 (8)

7(10)

5(10)

6(10)

 FSH (ng/ml) g

3.95 ± 2.50

2.67 ± 1.22

3.15 ± 1.65

1.58 ± 0.51

1.73 ± 0.64

1.46 ± 0.35

 LH (ng/ml)g

5.75 ± 3.04

4.86 ± 1.93

4.52 ± 3.38

1.83 ± 0.25

2.35 ± 1.11

2.16 ± 1.28

 PRL (ng/ml)g

102.34 ± 164.71c

27.49 ± 30.23

46.49 ± 31.03

 GH (ng/ml)

12.61 ± 13.30

3.85 ± 0.97c

4.16 ± 2.84

 TSH (ng/ml)

2.70 ± 1.13

3.02 ± 2.00

3.04 ± 1.53

1.29 ± 0.69e

1.93 ± 0.89f

3.03 ± 2.22e

 ACTH (pg/ml)

331.60 ± 89.59

314.09 ± 170.60

354.95 ± 104.96

 BDNF (pg/ml)

245.03 ± 155.68

483.62 ± 301.02

351.33 ± 177.28

25,399 ± 155.77e

377.79 ± 226.30f

249.39 ± 14,566e

  1. *Statistically significant (p < 0.05) with Kruskal-Wallis’ tests
  2. **Statistically significant (p < 0.01) with Kruskal-Wallis’ tests
  3. a7 out 8
  4. b9 out 10
  5. c6 out 8
  6. d5 out 8
  7. e4 out 10
  8. f2 out 10
  9. gNot statistically evaluated due to insufficient sample size after clustering on the basis of the estrous cycle