|
6 week cohort
|
13-week cohort
|
---|
Control
|
Glyphosate
|
Roundup
|
Control
|
Glyphosate
|
Roundup
|
---|
Serum Hormones
|
No. of females examined
|
8 (8)
|
8 (8)
|
8 (8)
|
10 (10)
|
10 (10)
|
10 (10)
|
TT (ng/ml)
|
0.66 ± 0.064
|
0.75 ± 0.12
|
0.68 ± 0.11a
|
0.51 ± 0.06
|
0.72 ± 0.10
|
0.72 ± 0.07b *
|
fT (pg/ml)
|
6.49 ± 1.00c
|
6.74 ± 1.89d
|
7.70 ± 1.35a
|
9.18 ± 2.49
|
12.04 ± 1.25
|
12.52 ± 1.76b
|
DHT (pg/ml)
|
294.28 ± 50.40
|
328.34 ± 51.93a
|
488.94 ± 114.68a
|
382.93 ± 52.14
|
460.09 ± 60.06
|
268.84 ± 45.56b
|
SHBG (ng/ml)
|
864.82 ± 30.24
|
952.75 ± 54.98
|
903.07 ± 29.61
|
968.27 ± 21.39
|
993.44 ± 32.79
|
964.81 ± 27.20
|
E2 (pg/ml)g
|
14.95 ± 7.24
|
32.24 ± 8.77
|
66.96 ± 25.17
|
18.08 ± 8.49
|
28.48 ± 13.71
|
43.91 ± 9.92
|
Plasma Hormones
|
No. of females examined
|
7 (8)
|
7 (8)
|
6 (8)
|
7(10)
|
5(10)
|
6(10)
|
FSH (ng/ml) g
|
3.95 ± 2.50
|
2.67 ± 1.22
|
3.15 ± 1.65
|
1.58 ± 0.51
|
1.73 ± 0.64
|
1.46 ± 0.35
|
LH (ng/ml)g
|
5.75 ± 3.04
|
4.86 ± 1.93
|
4.52 ± 3.38
|
1.83 ± 0.25
|
2.35 ± 1.11
|
2.16 ± 1.28
|
PRL (ng/ml)g
|
102.34 ± 164.71c
|
27.49 ± 30.23
|
46.49 ± 31.03
|
–
|
–
|
–
|
GH (ng/ml)
|
12.61 ± 13.30
|
3.85 ± 0.97c
|
4.16 ± 2.84
|
–
|
–
|
–
|
TSH (ng/ml)
|
2.70 ± 1.13
|
3.02 ± 2.00
|
3.04 ± 1.53
|
1.29 ± 0.69e
|
1.93 ± 0.89f
|
3.03 ± 2.22e
|
ACTH (pg/ml)
|
331.60 ± 89.59
|
314.09 ± 170.60
|
354.95 ± 104.96
|
–
|
–
|
–
|
BDNF (pg/ml)
|
245.03 ± 155.68
|
483.62 ± 301.02
|
351.33 ± 177.28
|
25,399 ± 155.77e
|
377.79 ± 226.30f
|
249.39 ± 14,566e
|
- *Statistically significant (p < 0.05) with Kruskal-Wallis’ tests
- **Statistically significant (p < 0.01) with Kruskal-Wallis’ tests
- a7 out 8
- b9 out 10
- c6 out 8
- d5 out 8
- e4 out 10
- f2 out 10
- gNot statistically evaluated due to insufficient sample size after clustering on the basis of the estrous cycle