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Table 9 Effects of glyphosate or Roundup Bioflow exposure on hormones in female (mean ± SEM)

From: The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

  6 week cohort 13-week cohort
Control Glyphosate Roundup Control Glyphosate Roundup
Serum Hormones
 No. of females examined 8 (8) 8 (8) 8 (8) 10 (10) 10 (10) 10 (10)
 TT (ng/ml) 0.66 ± 0.064 0.75 ± 0.12 0.68 ± 0.11a 0.51 ± 0.06 0.72 ± 0.10 0.72 ± 0.07b *
 fT (pg/ml) 6.49 ± 1.00c 6.74 ± 1.89d 7.70 ± 1.35a 9.18 ± 2.49 12.04 ± 1.25 12.52 ± 1.76b
 DHT (pg/ml) 294.28 ± 50.40 328.34 ± 51.93a 488.94 ± 114.68a 382.93 ± 52.14 460.09 ± 60.06 268.84 ± 45.56b
 SHBG (ng/ml) 864.82 ± 30.24 952.75 ± 54.98 903.07 ± 29.61 968.27 ± 21.39 993.44 ± 32.79 964.81 ± 27.20
 E2 (pg/ml)g 14.95 ± 7.24 32.24 ± 8.77 66.96 ± 25.17 18.08 ± 8.49 28.48 ± 13.71 43.91 ± 9.92
Plasma Hormones
 No. of females examined 7 (8) 7 (8) 6 (8) 7(10) 5(10) 6(10)
 FSH (ng/ml) g 3.95 ± 2.50 2.67 ± 1.22 3.15 ± 1.65 1.58 ± 0.51 1.73 ± 0.64 1.46 ± 0.35
 LH (ng/ml)g 5.75 ± 3.04 4.86 ± 1.93 4.52 ± 3.38 1.83 ± 0.25 2.35 ± 1.11 2.16 ± 1.28
 PRL (ng/ml)g 102.34 ± 164.71c 27.49 ± 30.23 46.49 ± 31.03 – – –
 GH (ng/ml) 12.61 ± 13.30 3.85 ± 0.97c 4.16 ± 2.84 – – –
 TSH (ng/ml) 2.70 ± 1.13 3.02 ± 2.00 3.04 ± 1.53 1.29 ± 0.69e 1.93 ± 0.89f 3.03 ± 2.22e
 ACTH (pg/ml) 331.60 ± 89.59 314.09 ± 170.60 354.95 ± 104.96 – – –
 BDNF (pg/ml) 245.03 ± 155.68 483.62 ± 301.02 351.33 ± 177.28 25,399 ± 155.77e 377.79 ± 226.30f 249.39 ± 14,566e
  1. *Statistically significant (p < 0.05) with Kruskal-Wallis’ tests
  2. **Statistically significant (p < 0.01) with Kruskal-Wallis’ tests
  3. a7 out 8
  4. b9 out 10
  5. c6 out 8
  6. d5 out 8
  7. e4 out 10
  8. f2 out 10
  9. gNot statistically evaluated due to insufficient sample size after clustering on the basis of the estrous cycle
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Environmental Health

ISSN: 1476-069X