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Table 4 Estimated additional weight (kg) change associated with phthalate biomarker concentrations, among controls only (N=660)

From: Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women: a prospective cohort study

Phthalate Biomarkers, ng/mL Adjusteda β (95% CI)
Year 3 Year 6
MEP
 2.80 - 33.10 ref ref
 33.20 - 67.90 0.07 (-1.35-1.49) -0.13 (-1.59-1.33)
 68.10 - 159.00 -0.28 (-1.71-1.16) -0.75 (-2.23-0.72)
 161.00 - 26000.00 2.32 (0.93-3.72) 1.04 (-0.38-2.47)
 P trend 0.001 0.15
MBP
 0.28 - 12.00 ref ref
 12.10 - 23.60 -0.52 (-1.98-0.95) 0.03 (-1.48-1.54)
 23.70 - 46.70 0.30 (-1.11-1.72) 0.50 (-0.96-1.96)
 46.80 - 3600.00 1.24 (-0.22-2.50) 0.70 (-0.69-2.10)
 P trend 0.05 0.26
MHBP
 0.28 - 0.90 ref ref
 1.00 - 1.90 -0.11 (-1.55-1.34) 0.33 (-1.16-1.82)
 2.00 - 3.90 0.62 (-0.78-2.02) -0.02 (-1.45-1.42)
 4.00 - 490.00 1.04 (-0.30-2.28) 0.92 (-0.44-2.29)
 P trend 0.09 0.23
ΣDBP, μmol/L
 0.002 - 0.065 ref Ref
 0.0652 - 0.132 -0.20 (-1.59-1.19) -0.20 (-1.63-1.23)
 0.133 - 0.264 1.06 (-0.32-2.43) 0.56 (-0.86-1.97)
 0.265 - 18.255 0.84 (-0.54-2.22) 0.61 (-0.81-2.03)
 P trend 0.11 0.29
MiBP
 0.14 - 1.00 ref ref
 1.10 - 2.10 -0.48 (-1.83-0.87) 0.12 (-1.27-1.51)
 2.20 - 4.10 0.49 (-0.88-1.85) -0.48 (-1.88-0.92)
 4.20 - 212.00 -0.27 (-1.63-1.10) -0.37 (-1.77-1.03)
 P trend 0.99 0.48
MHiBP
 0.28 - 0.40 ref ref
 0.50 - 0.80 0.28 (-1.06-1.62) 0.79 (-0.59-2.17)
 0.90 - 1.60 -0.34 (-1.71-1.04) -0.61 (-2.02-0.81)
 1.70 - 91.70 1.98 (0.62-3.33) 1.12 (-0.26-2.50)
 P trend 0.02 0.33
ΣDiBP, μmol/L
 0.002 - 0.0057 ref ref
 0.006 - 0.0123 0.15 (-1.24-1.54) 1.01 (-0.43-2.44)
 0.0124 - 0.0247 -0.10 (-1.46-1.27) -0.14 (-1.54-1.27)
 0.0248 - 1.339 0.95 (-0.44-2.34) 0.15 (-1.28-1.57)
 P trend 0.24 0.81
MBzP
 0.40 - 5.90 ref ref
 6.00 - 12.00 -0.14 (-1.55-1.26) -0.04 (-1.49-1.41)
 12.10 - 22.20 -0.44 (-1.87-0.98) -0.06 (-1.54-1.42)
 22.30 - 3590.00 0.94 (-0.47-2.35) -0.45 (-1.91-1.01)
 P trend 0.24 0.54
MCPP
 0.14 - 1.70 ref Ref
 1.80 - 3.00 0.30 (-1.13-1.73) 0.38 (-1.10-1.86)
 3.10 - 5.40 -0.65 (-2.07-0.77) -0.64 (-2.10-0.82)
 5.50 - 108.00 0.71 (-0.67-2.10) -0.13 (-1.55-1.30)
 P trend 0.46 0.62
MEHP
 0.35 - 0.90 ref ref
 1.00 - 1.90 0.34 (-1.07-1.75) -0.15 (-1.60-1.31)
 2.00 - 4.10 0.70 (-0.65-2.04) 0.54 (-0.84-1.91)
 4.20 - 367.00 -0.24 (-1.66-1.19) 0.41 (-1.66-1.19)
 P trend 0.96 0.44
MEHHP
 0.60 - 9.20 ref ref
 9.30 - 17.10 -0.25 (-1.67-1.17) -0.25 (-1.71-1.21)
 17.20 - 33.00 -0.16 (-1.51-1.18) 0.05 (-1.77-1.07)
 33.20 - 2830.00 1.06 (-0.32-2.44) -0.35 (-1.77-1.07)
 P trend 0.17 0.73
MEOHP
 0.20 - 5.80 ref ref
 5.90 - 10.60 0.15 (-1.26-1.56) -0.11 (-1.57-1.36)
 10.70 - 20.40 0.23 (-1.13-1.59) 0.21 (-1.18-1.60)
 20.50 - 1610.00 1.44 (0.07-2.80) 0.15 (-1.25-1.55)
 P trend 0.05 0.76
MECPP
 1.10 - 12.90 ref ref
 13.00 - 22.60 0.58 (-0.81-1.98) 0.88 (-0.55-2.32)
 22.70 - 41.50 -0.09 (-1.43-1.25) 0.12 (-1.26-1.50)
 41.60 - 2460.00 1.26 (-0.14-2.66) -0.09 (-1.52-1.35)
 P trend 0.17 0.73
ΣDEHP, μmol/L
 0.008 - 0.1007 ref ref
 0.1008 - 0.1827 -0.20 (-1.59-1.18) -0.30 (-1.73-1.13)
 0.1828 - 0.341 -0.01 (-1.37-1.34) 0.07 (-1.32 -1.46)
 0.343 - 24.419 1.02 (-0.39-2.43) -0.41 (-1.87-1.04)
 P trend 0.18 0.71
MCOP
 0.14 - 2.10 ref ref
 2.20 - 3.60 0.37 (-0.98-1.72) 0.71 (-0.68-2.11)
 3.70 - 6.50 0.23 (-1.20-1.66) -0.72 (-2.20-0.75)
 6.60 - 239.00 -1.17 (-2.54-0.21) -0.50 (-1.92-0.92)
 P trend 0.09 0.25
MCNP
 0.14 - 1.50 ref ref
 1.60 - 2.60 -0.36 (-1.75-1.03) -0.11 (-1.54-1.33)
 2.70 - 4.70 -0.09 (-1.49-1.32) 0.11 (-1.35-1.56)
 4.80 - 91.60 -0.39 (-1.77-0.98) -1.03 (-2.46-0.39)
 P trend 0.65 0.17
  1. Abbreviations used: CI confidence interval, MEP monoethyl phthalate, MBP monobutyl phthalate, MHBP mono-hydroxybutyl phthalate, DBP dibutyl phthalate, MiBP mono-isobutyl phthalate, phthalate MHiBP mono-hydroxyisobutyl phthalate, DiBP di-isobutyl phthalate, MBzP monobenzyl phthalate, MCPP mono(3-carboxypropyl) phthalate, MEHP mono(2-ethylhexyl) phthalate, MEHHP mono(2-ethyl-5-hydroxyhexyl) phthalate, MEOHP mono(2-ethyl-5-oxohexyl), DEHP di(2-ethylhexyl)phthalate, MECPP mono(2-ethyl-5-carboxypentyl) phthalate, MCOP mono-carboxyoctyl phthalate, MCNP mono-carboxynonyl phthalate
  2. aAdjusted for creatinine, age, ethnicity, alcohol use, physical activity, smoking status, healthy eating index, dietary energy intake, hormone replacement therapy use, education, income, and history of diabetes, hypertension, dyslipidemia and cardiovascular diseases