PFAS
|
Communication ARR (95% CI)
|
Gross motor ARR (95% CI)
|
Fine motor ARR (95% CI)
|
Problem solving ARR (95% CI)
|
Personal–social skills ARR (95% CI)
|
---|
Girl (N = 236)
|
Boy (N = 297)
|
Girl (N = 236)
|
Boy (N = 297)
|
Girl (N = 236)
|
Boy (N = 297)
|
Girl (N = 236)
|
Boy (N = 297)
|
Girl (N = 236)
|
Boy (N = 297)
|
---|
PFHxS
|
Low tertile
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
| Ref☆ |
Middle tertile
|
0.99 (0.53, 1.83)
|
0.64 (0.39, 1.05)
|
1.55 (0.68, 3.55)
|
0.76 (0.35, 1.67)
|
1.46 (0.35, 6.10)
|
0.55 (0.27, 1.13)
|
0.81 (0.35, 1.89)
|
0.85 (0.44, 1.64)
|
1.62 (0.43, 6.08)
|
0.68 (0.30, 1.55)
|
High tertile
|
1.24 (0.65, 2.36)
|
0.90 (0.59, 1.36)
|
1.43 (0.55, 3.68)
|
0.57 (0.26, 1.24)
|
0.50 (0.05, 5.00)
|
0.73 (0.40, 1.36)
|
1.24 (0.48, 3.21)
|
0.61 (0.32, 1.18)
|
2.56 (0.73, 9.03)
|
1.77 (0.94, 3.34)
|
PFOS
|
Low tertile
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
| Ref☆ |
Ref
|
Middle tertile
|
0.52 (0.26, 1.04)#
|
1.16 (0.76, 1.77)
|
0.81 (0.27, 2.43)
|
0.94 (0.43, 2.07)
|
0.79 (0.13, 4.91)
|
1.87 (0.92, 3.80)#
|
0.55 (0.15, 2.07)
|
1.21 (0.65, 2.28)
|
0.32 (0.04, 2.77)
|
1.47 (0.76, 2.84)
|
High tertile
|
1.10 (0.63, 1.92)
|
0.89 (0.53, 1.51)
|
1.61 (0.62, 4.16)
|
0.91 (0.37, 2.24)
|
1.98 (0.34, 11.53)
|
1.19 (0.52, 2.71)
|
2.00 (0.77, 5.17)
|
0.66 (0.29, 1.48)
|
2.97 (0.90, 9.84)#
|
1.18 (0.57, 2.44)
|
PFOA
|
Low tertile
| Ref☆ |
Ref
|
Ref
| Ref☆ |
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Middle tertile
|
0.86 (0.49, 1.50)
|
1.02 (0.65, 1.6)
|
1.08 (0.33, 3.57)
|
0.51 (0.23, 1.11)#
|
0.50 (0.13, 1.93)
|
0.88 (0.43, 1.80)
|
0.93 (0.35, 2.46)
|
1.09 (0.56, 2.12)
|
not converge
|
1.60 (0.80, 3.19)
|
High tertile
|
0.55 (0.28, 1.10)#
|
0.96 (0.61, 1.52)
|
1.90 (0.66, 5.44)
|
0.45 (0.19, 1.04)#
|
1.32 (0.29, 5.93)
|
0.91 (0.47, 1.78)
|
0.90 (0.36, 2.26)
|
1.10 (0.58, 2.06)
|
not converge
|
1.50 (0.77, 2.93)
|
PFNA
|
Low tertile
| Ref★ |
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
| Ref★ |
Ref
|
Middle tertile
|
0.73 (0.41, 1.32)
|
1.19 (0.76, 1.88)
|
0.96 (0.29, 3.20)
|
0.91 (0.39, 2.08)
|
1.15 (0.25, 5.24)
|
1.72 (0.82, 3.62)
|
0.56 (0.20, 1.55)
|
1.24 (0.64, 2.43)
|
2.87 (0.37, 22.20)
|
1.23 (0.62, 2.47)
|
High tertile
|
0.50 (0.26, 0.94)*
|
1.17 (0.72, 1.91)
|
1.50 (0.54, 4.21)
|
1.06 (0.48, 2.35)
|
0.46 (0.10, 2.11)
|
1.72 (0.82, 3.59)
|
0.93 (0.4, 2.17)
|
1.08 (0.52, 2.25)
|
5.68 (0.82, 39.34)
|
1.70 (0.86, 3.36)
|
PFDA
|
Low tertile
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
| Ref★ |
Ref
|
Middle tertile
|
0.61 (0.31, 1.20)
|
1.01 (0.66, 1.55)
|
1.16 (0.36, 3.71)
|
0.87 (0.42, 1.81)
|
2.04 (0.43, 9.66)
|
1.65 (0.87, 3.13)
|
0.50 (0.14, 1.74)
|
1.27 (0.69, 2.33)
|
2.16 (0.26, 17.69)
|
1.14 (0.57, 2.28)
|
High tertile
|
1.02 (0.54, 1.91)
|
0.88 (0.55, 1.42)
|
1.83 (0.62, 5.39)
|
0.53 (0.21, 1.32)
|
0.40 (0.03, 4.74)
|
0.80 (0.37, 1.76)
|
1.71 (0.70, 4.15)
|
0.65 (0.31, 1.36)
|
8.68 (1.41, 53.43)*
|
1.52 (0.74, 3.09)
|
PFUdA
|
Low tertile
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
| Ref☆ |
Ref
|
Middle tertile
|
0.64 (0.32, 1.25)
|
1.18 (0.78, 1.80)
|
0.44 (0.12, 1.53)
|
1.14 (0.54, 2.43)
|
2.10 (0.43, 10.41)
|
2.19 (1.16, 4.17)*
|
0.27 (0.05, 1.33)
|
1.57 (0.81, 3.03)
|
0.79 (0.11, 5.56)
|
1.77 (0.90, 3.47)#
|
High tertile
|
0.93 (0.52, 1.66)
|
0.83 (0.50, 1.38)
|
1.29 (0.53, 3.16)
|
0.77 (0.31, 1.92)
|
1.35 (0.18, 10.02)
|
0.64 (0.26, 1.56)
|
1.35 (0.62, 2.94)
|
0.88 (0.40, 1.90)
|
3.72 (0.79, 17.62)#
|
1.12 (0.48, 2.63)
|
PFDoA
|
Low tertile
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
| Ref★ |
Ref
|
Middle tertile
|
0.78 (0.38, 1.58)
|
1.29 (0.82, 2.04)
|
0.81 (0.27, 2.38)
|
0.88 (0.41, 1.91)
|
0.48 (0.11, 2.06)
|
1.34 (0.70, 2.56)
|
1.25 (0.35, 4.41)
|
1.06 (0.54, 2.06)
|
3.99 (0.46, 34.3)
|
0.91 (0.47, 1.77)
|
High tertile
|
1.33 (0.72, 2.46)
|
1.14 (0.72, 1.82)
|
1.27 (0.51, 3.19)
|
0.93 (0.41, 2.09)
|
0.40 (0.07, 2.37)
|
0.84 (0.41, 1.75)
|
1.78 (0.61, 5.23)
|
1.13 (0.58, 2.18)
|
6.89 (0.97, 48.67)#
|
0.91 (0.46, 1.79)
|
PFTrDA
|
Low tertile
|
Ref
|
Ref’
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Ref
|
Middle tertile
|
1.19 (0.60, 2.36)
|
1.53 (0.92, 2.55)
|
0.94 (0.33, 2.66)
|
2.25 (0.82, 6.14)
|
0.44 (0.10, 1.98)
|
1.90 (0.86, 4.20)
|
1.69 (0.64, 4.47)
|
1.46 (0.75, 2.84)
|
0.79 (0.21, 2.96)
|
1.70 (0.85, 3.4)
|
High tertile
|
1.36 (0.69, 2.69)
|
1.83 (1.08, 3.12)*
|
0.85 (0.31, 2.29)
|
1.68 (0.56, 5.1)
|
0.28 (0.05, 1.61)
|
1.81 (0.78, 4.19)
|
0.88 (0.31, 2.52)
|
0.71 (0.29, 1.73)
|
0.84 (0.23, 3.03)
|
1.29 (0.61, 2.75)
|
- Models were adjusted for maternal age at enrollment (ages), pre-pregnancy BMI (kg/m2), maternal education, paternal education, parity, per capita household income (< 4000, 4000–8000, and > 8000 CNY), maternal passive smoking (yes or no), maternal prenatal depressive symptoms (yes or no), and gestational age (weeks)
- ARR Adjusted risk ratio, CI Confidence interval
- # Marginally significant differences (0.05 < p < 0.10)
- * Statistically significant differences (p < 0.05)
- ★p-trend < 0.05
- ☆0.05 < p-trend < 0.10