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Table 5 Univarite analysis of associations among the study parameters

From: Correction to: Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study

Ā 

Coefficient Ī² (95% CI)

Ā 

DNA base damage

DNA strand breaks

Micronucleus frequency

Arsenic concentration

Ā 

8-OHdG

8-nitro

guanine

Tail length

Olive tail moment

%DNA in tail

Mono

nucleated

Bi

nucleated

Urine (Ī¼g/g creatinine)

Cord blood

Toenail

Arsenic exposure

Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Maternal toenail

0.068**

0.244**

0.112***

0.083*

0.131**

0.698**

-0.045

0.225***

0.126**

Ā 
Ā 

(0.023,0.133)

(0.078,0.410)

(0.056,0.168)

(0.017,0.149)

(0.056,0.207)

(0.272,1.124)

(-0.167,0.077)

(0.113,0.336)

(0.043,0.209)

Ā 

Maternal urine

Ā Ā Ā Ā Ā 

Total As

0.003

-0.017

0.058

0.135**

0.100*

0.378

0.128

Ā Ā Ā 
Ā 

(-0.054,0.061)

(-0.229,0.196)

(-0.014,0.129)

(0.051,0.220)

(0.004,0.197)

(-0.166,0.922)

(-0.028,0.084)

Ā Ā Ā 

iAs

-0.021

0.155

-0.009

0.043

0.02

-0.085

0.051

-0.054

0.007

-0.184

Ā 

(-0.079,0.037)

(-0.060,0.371)

(-0.081,0.064)

(-0.043,0.129)

(-0.078,0.118)

(-0.637,0.468)

(-0.107,0.209)

(-0.205,0.097)

(-0.103,0.117)

(-0.375,0.007)

MMA

0.019

0.141

0.010

0.047

0.039

0.496

0.115

-0.107

0.054

0.215*

Ā 

(-0.039,0.077)

(-0.075,0.356)

(-0.063,0.082)

(-0.039,0.133)

(-0.059,0.137)

(-0.056,1.048)

(-0.043,0.273)

(-0.257,0.043)

(-0.056,0.163)

(0.025,0.405)

DMA

-0.01

-0.238

0.011

-0.057

-0.025

-0.146

-0.070

0.445***

-0.097

0.003

Ā 

(-0.075,0.055)

(-0.475,0.003)

(-0.070,0.092)

(-0.153,0.039)

(-0.135,0.084)

(-0.763,0.470)

(-0.246,0.106)

(0.290,0.600)

(-0.218,0.025)

(-0.212,0.218)

Cord blood

-0.056

-0.086

0.192***

0.256***

0.244***

0.456

0.774***

0.042

Ā Ā 
Ā 

(-0.135,0.023)

(-0.379,0.206)

(0.094,0.290)

(0.140,0.373)

(0.111,0.377)

(-0.292,1.204)

(0.560,0.988)

(-0.163,0.246)

Ā Ā 

DNA damage

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

8-OHdG

Ā 

0.025

0.082

-0.119

0.040

0.016

-0.035

Ā Ā Ā 
Ā Ā 

(-0.021,0.071)

(-0.083,0.247)

(-0.356,0.119)

(-0.148,0.229)

(-0.007,0.038)

(-0.096,0.026)

Ā Ā Ā 

8-nitroguanine

Ā Ā 

0.043

0.170

0.459

-0.008

-0.063

Ā Ā Ā 
Ā Ā Ā 

(-0.563,0.649)

(-0.700,1.040)

(-0.226,1.144)

(-0.091,0.075)

(-0.286,0.160)

Ā Ā Ā 

DNA strand breaks

Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Tail length

Ā Ā Ā 

0.432***

0.063

0.002

0.064*

Ā Ā Ā 
Ā Ā Ā Ā 

(0.201,0.663)

(-0.128,0.255)

(-0.021,0.026)

(0.003,0.125)

Ā Ā Ā 

Olive tail moment

Ā Ā Ā 

0.574***

0.033***

0.008

Ā Ā Ā 
Ā Ā Ā Ā Ā 

(0.482,0.666)

(0.018,0.048)

(-0.035,0.051)

Ā Ā Ā 

%DNA in tail

Ā Ā Ā Ā Ā 

0.003

0.019

Ā Ā Ā 
Ā Ā Ā Ā Ā Ā 

(-0.018,0.023)

(-0.036,0.074)

Ā Ā Ā 
  1. *, **,***Statistically significant association at p < 0.05, p < 0.01 and p < 0.001, respectively
  2. Ī² represents standardized coefficient; 95% CI represents 95% confidence interval (CI)
  3. Olive tail moment is the product of the tail length and the fraction of total DNA in the tail
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Environmental Health

ISSN: 1476-069X