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Table 2 Association of SUA with LnBLL among 8303 12–19 year-old adolescents, NHANES 1999–2006

From: Association of low-level blood lead with serum uric acid in U.S. adolescents: a cross-sectional study

LnBLL, μg/dL SUA, mg/dL, β (95%CI), P value
Crude model Model 1 Model 2 Model 3 Model 4
Per 1 μg/dL increase 0.29 (0.24, 0.33), < 0.001 0.14 (0.11, 0.18), < 0.001 0.14 (0.10, 0.17), < 0.001 0.13 (0.09, 0.17), < 0.001 0.14 (0.10, 0.17), < 0.001
Quartiles
 Q1 (< −0.22) Reference (0) Reference (0) Reference (0) Reference (0) Reference (0)
 Q2 (−0.22–0.18) 0.23 (0.17, 0.30), < 0.001 0.13 (0.08, 0.19), < 0.001 0.11 (0.05, 0.16), < 0.001 0.10 (0.05, 0.16), < 0.001 0.11 (0.05, 0.16), < 0.001
 Q3 (0.18–0.64) 0.31 (0.23, 0.38), < 0.001 0.13 (0.07, 0.19), < 0.001 0.11 (0.05, 0.17), < 0.001 0.10 (0.04, 0.16), 0.001 0.11 (0.05, 0.17), < 0.001
 Q4 (≥ 0.64) 0.51 (0.43, 0.60), < 0.001 0.26 (0.19, 0.33), < 0.001 0.26 (0.19, 0.33), < 0.001 0.24 (0.17, 0.31), < 0.001 0.26 (0.19, 0.33), < 0.001
P for trend < 0.001 < 0.001 < 0.001 < 0.001 < 0.001
  1. Model 1was adjusted for sex, age, BMI, race, education status and physical activity
  2. Model 2 was adjusted for all covariables in model 1 plus adjusted for SBP, DBP, blood cadmium, serum cotinine, hemoglobin, fasting blood glucose, total cholesterol, triglycerides, HDL-C, eGFR, blood urea nitrogen and C-reactive protein
  3. Model 3 was adjusted for all covariables in model 2 plus adjusted for calcium intake, total monounsaturated fatty acids intake, total polyunsaturated fatty acids intake, total saturated fatty acids intake, total fat intake and total protein intake
  4. Model 4 was adjusted for sex, age, BMI, race, hemoglobin, HDL-C and eGFR. The covariance was determined based on the matched odds ratio changed at least 10% when added to this model
  5. Abbreviations: BLL blood lead levels, SUA serum uric acid, CI confidence interval