Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study

Table 2 Associations between outdoor air pollution and plasma FlOPs levels

		NO₂	NO_x	PM₁₀^a	PM_2.5^a	Total traffic load on major roads in a 100-m buffer of the home^b	Traffic intensity at the road nearest to a participant’s home^b	O₃	O_3-sumer
Model 1	n β crude (95% CI) P	204 0.007 (− 0.004,0.02) 0.19	204 0.006 (− 0.003,0.02) 0.15	146 0.04 (0.001,0.08) 0.04	146 0.03 (− 0.009,0.07) 0.15	204 0.008 (− 0.005,0.02) 0.24	204 0.0004 (− 0.005,0.006) 0.88	204 0.03 (− 0.004,0.06) 0.06	204 0.02 (− 0.03,0.07) 0.36
Model 2	n β adjusted (95% CI) P	204 0.007 (− 0.003,0.02) 0.18	204 0.007 (− 0.002,0.02) 0.16	146 0.04 (0.001,0.08) 0.03	146 0.03 (− 0.008,0.07) 0.18	204 0.006 (− 0.006,0.02) 0.30	204 0.0002 (− 0.005,0.006) 0.94	204 0.04 (0.009,0.07) 0.02	204 0.02 (− 0.02,0.06) 0.45
Model 3	n β adjusted (95% CI) P	204 0.007 (− 0.002,0.02) 0.14	204 0.006 (− 0.002,0.01) 0.12	72 0.03 (− 0.01,0.07) 0.22^c
Model 4	n β adjusted (95% CI) P	186 0.009 (− 0.003,0.02) 0.14	186 0.008 (− 0.002,0.02) 0.14	133 0.05 (0.006,0.09) 0.04	133 0.02 (− 0.02,0.06) 0.24	186 0.003 (− 0.01,0.02) 0.63	186 0.0005 (− 0.005,0.006) 0.86	186 0.05 (0.01,0.08) 0.01	186 0.02 (− 0.03,0.07) 0.37

The linear regression models were conducted with random effects on familial dependence and center. FlOPs levels were log₁₀-transformed. NO₂, nitrogen dioxide; NO_x, nitrogen oxides; PM₁₀, particulate matter with a diameter ≤ 10 μm; PM_2.5, particulate matter with a diameter ≤ 5 μm. Results are expressed per 20 μg/m³ increase of NO_x exposure, per 10 μg/m³ increase of NO₂, PM₁₀ O₃ and O_3-summer exposures, per 5 μg/m³ increase of PM_2.5 exposure, per 4 million vehicles x meters per day increase of total traffic load, per 5000 vehicles per day increase of traffic intensity. Model 1: unadjusted. Model 2: adjusted for age, sex and smoking status. Model 3: with back-extrapolated pollution and adjusted for age, sex and smoking status. Model 4: after excluding the participants living at the same residential address <1 year
^aNot back-extrapolated PM were only estimated in Paris and in Grenoble, and back extrapolated PM₁₀ only in Paris
^bEstimates were also adjusted for background NO₂
^cThe linear regression model was only conducted with random effects on familial dependence because back-extrapolated PM₁₀ were estimated only in Paris

ISSN: 1476-069X