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Table 5 Weighted Mean Difference (95% Confidence Interval) of Lung Function at Visit 2 (1993–1995) by Urinary Arsenic Concentration at Baseline (1989–1991)

From: Low-moderate arsenic exposure and respiratory in American Indian communities in the Strong Heart Study

 NInorganic Plus Methylated Arsenic Species μg/g creatinineP-trendd
Tertile 1
≤7.0b
Tertile 2
7.1–13.9b
Tertile 3
≥14.0b
75th vs. 25th Percentilec
FEV1, % predicted
 All21320 (Ref)0.92 (−0.52, 2.37)−1.64 (−3.60, 0.32)−1.39 (−2.51, −0.25)0.02
 Healthya13670 (Ref)0.67 (−0.86, 2.19)−0.49 (−2.58, 1.61)0.85 (0.27, 2.74)0.80
FVC, % predicted
 All21320 (Ref)2.09 (0.72, 3.47)−1.01 (−2.85, 0.83)−1.13 (−2.21, − 0.05)0.04
 Healthya13670 (Ref)1.15 (− 0.23, 2.53)− 0.73 (− 2.60, 1.14)0.70 (0.24, 2.02)0.50
FEV1/FVC (%)
 All21320 (Ref)−0.62 (−1.26, 0.002)− 0.16 (− 1.01, 0.69)0.09 (− 0.46, 0.66)0.74
 Healthya13670 (Ref)− 0.31 (− 0.85, 0.25)0.26 (− 0.49, 1.01)1.21 (0.76, 1.94)0.42
FEV1, mL
 All21320 (Ref)0.007 (−0.04, 0.06)−0.09 (− 0.15, − 0.03)−0.07 (− 0.11, − 0.03)< 0.001
 Healthya13670 (Ref)0.003 (− 0.05, 0.06)−0.06 (− 0.14, 0.01)−0.03 (− 0.07, − 0.003)0.07
FVC, mL
 All21320 (Ref)0.06 (−0.004, 0.11)−0.10 (− 0.17, − 0.02)−0.07 (− 0.12, − 0.03)0.001
 Healthya13670 (Ref)0.02 (− 0.05, 0.09)−0.09 (− 0.19, − 0.0001)−0.05 (− 0.10, − 0.004)0.03
  1. Adjusted for age, sex, education, site, smoking status, smoking pack-year, eGFR, tuberculosis, and BMI
  2. aHealthy: FEV1/FVC > 0.70 & FVC > 80% predicted
  3. bTertiles are range; calculated based on overall population; sum of inorganic and methylated species μg/g creatinine
  4. cComparison of the 75th and 25th percentiles (interquartile range) of the sum inorganic and methylated urinary arsenic concentrations (16.7 vs. 5.8 μg/g creatinine)
  5. dP-trend calculated modeling log-arsenic as continuous