Skip to main content

Advertisement

Table 3 Adjusted odds ratio (OR) and 95% confidence intervals (95% CI) for asthma outcomes (wheeze, self-reported and doctor-diagnosed asthma) by multiple logistic regression in the 5-year-old offspring for a doubling in maternal serum-PFAS concentrations (ng/ml). Results also stratified by sex

From: Association between prenatal exposure to perfluoroalkyl substances and asthma in 5-year-old children in the Odense Child Cohort

All (n = 981)
Boys/ Girls (n = 511/470)
nWheezeSelf-reported asthmaDoctor-diagnosed asthma
nOR (95% CI)nOR (95% CI)nOR (95% CI)
PFOS
 Unadjusted model9811820.99 (0.78,1.26)251.25 (0.68,2.32)440.80 (0.53,1.23)
 Adjusted modela9701771.01 (0.79,1.30)251.22 (0.65,2.28)430.83 (0.52,1.31)
 Boysb5071171.02 (0.74,1.39)132.39 (0.92,6.21)370.74 (0.46,1.20)
 Girlsb3635601.01 (0.67,1.52)120.67 (0.29,1.53)61.60 (0.46,5.59)
 pi-value  0.96 0.048* 0.26
PFOA
  Unadjusted model9811821.01 (0.83,1.23)251.61 (0.99,2.63)440.84 (0.58,1.22)
 Adjusted modela9701770.98 (0.78,1.23)251.57 (0.93,2.68)430.81 (0.53,1.22)
 Boysb5071170.94 (0.71,1.23)132.17* (1.07,4.42)370.72 (0.46,1.12)
 Girlsb363601.08 (0.75,1.55)121.06 (0.49,2.30)61.70 (0.63,4.56)
 pi-value  0.52 0.17 0.11
PFHxS
 Unadjusted model9811821.04 (0.87,1.25)251.16 (0.74,1.84)441.02 (0.73,1.43)
 Adjusted modela9701771.13 (0.93,1.38)251.18 (0.73,1.90)431.16 (0.78,1.71)
 Boysb5071171.03 (0.80,1.34)131.33 (0.66,2.71)370.89 (0.59,1.34)
 Girlsb363601.29 (0.94,1.77)121.04 (0.55,1.98)62.96* (1.26,6.96)
 pi-value  0.28 0.61 0.013*
PFNA
  Unadjusted model9811821.04 (0.81,1.34)251.85* (1.06,3.23)440.70 (0.43,1.13)
 Adjusted modela9701771.03 (0.79,1.33)251.84* (1.03,3.28)430.68 (0.41,1.14)
 Boysb5071170.93 (0.67,1.29)132.11 (0.97,4.58)370.58 (0.33,1.03)
 Girlsb363601.22 (0.79,1.87)121.50 (0.64,3.49)61.52 (0.47,4.97)
 pi-value  0.32 0.56 0.15
PFDA
  Unadjusted model9811821.16 (0.93,1.44)251.37 (0.83,2.26)440.93 (0.61,1.42)
 Adjusted modela9701771.16 (0.93,1.46)251.44 (0.87,2.41)430.93 (0.60,1.44)
 Boysb5071171.21 (0.92,1.60)131.08 (0.51,2.29)370.91 (0.57,1.45)
 Girlsb363601.08 (0.73,1.58)121.88 (0.93,3.80)61.11 (0.38,3.29)
 pi-value  0.62 0.28 0.73
  1. a: adjusted for parity, maternal educational level, maternal pre-pregnancy BMI, asthma predisposition and child sex
  2. b: adjusted for parity, maternal educational level, maternal pre-pregnancy BMI and asthma predisposition
  3. i: p-value for PFAS*child sex interaction
  4. *: p < 0.05