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Table 1 Long-term chronic dietary exposure toxicity and carcinogenicity studies of glyphosate analyzed in this evaluation. Additional information on these studies is available in the Additional file 1

From: A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies

Study ReferenceDuration (months)StrainDietary exposure dose levels (mg/kg/day)Animals per GroupPurity (%)Comments on survival and weight
MouseRat
A: Knezevich and Hogan (1983) [11]24CD-1 M: 0, 157, 814, 4841
F: 0, 190, 955, 5874
5099.8No survival differences, slight weight reduction in high dose (M)
B: Atkinson et al. (1993) [12]24CD-1 M: 0, 98, 297, 988
F: 0, 102, 298, 1000
50> 97.0No survival differences, no weight differences
C: Sugimoto (1997) [13]18CD-1 M: 0, 165, 838.1, 4348
F: 0, 153.2, 786.8, 4116
5094.6–95.7No survival differences, slight weight reduction in mid (F) & high dose (M + F)
D: Wood et al. (2009) [14]18CD-1 M: 0, 71.4, 234.2, 810
F: 0, 97.9, 299.5, 1081.2
5195.7No survival differences, no weight differences
E: Takahashi (1999a) [15]18CD-1 M: 0, 167.6, 685, 7470
F: 0, 93.2, 909, 8690
5097.5Reduced survival high dose (M), slight weight reduction in mid (M) & high dose (M + F). This study was only mentioned by JMPR [7] and provides limited tumor data.
F: Kumar (2001) [16]18S-Aa M: 0, 85.5, 285.2, 1077.4
F: 0, 104.5, 348.6, 1381.9
50> 95.0No survival differences, no weight differences
G: Lankas (1981) [17]26 SDbM: 0, 3.05, 10.3, 31.49
F: 0, 3.37, 11.22, 34.02
5098.7No survival differences, no weight differences
H: Stout and Ruecker (1990) [18]24 SDbM: 89, 362, 940
F: 0, 113, 457, 1183
5098.7No survival differences, slight weight reduction in high dose (F)
I: Atkinson (1993) [19]24 SDbM: 0, 11, 112, 320, 1147
F: 0, 12, 109, 347, 1134
5098.9No survival differences, slight weight reduction in high dose (M + F)
J: Enemoto (1997) [20]24 SDbM: 0, 104, 354, 1127
F: 0, 115, 393, 1247
5095.7Reduced survival high dose (M), slight weight reduction in high dose (M + F)
K: Suresh (1996) [21]24 WcM: 0, 6.3, 59.4, 595.2
F: 0, 8.6, 88.5, 886
5096.8No survival differences, no weight differences
L: Brammer (2001) [22]24 WcM: 0, 121, 361, 1214
F: 0, 145, 437, 1498
5397.6High-dose survived longer (M), reduced weight highest dose (M + F)
M: Wood et al. (2009) [23]24 WcM: 0, 165, 838.1, 4348
F: 0, 153.2, 786.8, 4116
5194.7–97.6No survival differences, no weight differences
  1. aSwiss Albino mouse; bSprague-Dawley rat; cWistar rat