Table 1 Chemical concentrations tested in vitro (Phase 1) in relation to concentrations found in human samples

Lead(II) chloride

Lead

200, 50, 12.50, 3.13, 0.78, 0.20 μM

Cord blood:

range 1.09–11.41 μg/L ➔0.0039–0.041 μM

Children blood:

Range 1.71–10 μg/dL ➔0.061–0.36 μM

IPChem:

Blood-whole blood: 3.76–69, 3.42–28.8, 4.13–43.6, 6.05–23.1 μg/L (range 3.42–69) ➔ 0.012–0.25 μM

Cord blood-whole blood (considering for plasma, 1.025 g/mL) 2.68–36.4 ng/g ➔ 0.00988–0.13 μM

Chlorpyrifos

CPF

500, 125, 31.25, 7.81, 1.95, 0.49 μM

Cord plasma:

4.65 ng/mL ➔ 0.013 μM

Cord blood:

Range 2.5–6.17 pg/g plasma (considering for plasma, 1.025 g/mL) ➔ 7.3 × 10^− 6 - 1.8 × 10^− 5 μM

Bisphenol A

BPA

400, 100, 25, 6.25, 1.56, 0.39, 0.10 μM

Children serum:

Range 0.85–22.5 ng/mL ➔ 0.0037–0.098 μM

IPChem:

Blood – plasma: n.d.- 3.5 ng/g (considering for plasma, 1.025 g/mL) ➔ n.d. - 0.016 μM

Cord blood-whole blood: n.d.-1.9 ng/g (considering for plasma, 1.025 g/mL) ➔ n.d. - 0.0085 μM

Methyl-mercury(II) chloride

Methyl-Hg

10, 2.50, 0.63, 0.16, 0.04, 0.01, 0.0024, 0.0006 μM

Cord blood:

range 0.70–35 μg/L ➔ 0.0028–0.14 μM

Children blood:

Range 1.46–6.81 μg/L ➔ 0.0058–0.027 μM

IPChem:

Blood-whole blood: 0.11–10.2, 0.002–4.17, 0.19–7.93, 0.13–5.95 μg/L (range 0.002–10.2) ➔ 8 × 10^− 6 - 0.041 μM

Cord blood-whole blood: 0.16–14.1 ng/g (considering for plasma, 1.025 g/mL) ➔0.00065–0.058 μM

Cord blood-whole blood: n.d. - 8.4 μg/L ➔ n.d.-0.033 μM

Blood –plasma: n.d. - 4.2 μg/L ➔ n.d.- 0.017 μM

Valproic acid

VA

10.000, 2500, 625, 156, 39, 10 μM

Cord blood:

Range 3.87–75 μg/ml ➔ 26.8–520 μM

PCB138

PCB138

100, 25, 6.25, 1.56, 0.39, 0.10, 0.02 μM

Cord plasma:

Range 0.14–0.18 ng/mL ➔ 3.87 × 10^− 4 - 5 × 10^− 4 μM

IPChem:

cord plasma: 270–460 ng/L ➔ 0.00075–0.0013 μM