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Table 1 Chemical concentrations tested in vitro (Phase 1) in relation to concentrations found in human samples

From: Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept

ChemicalAbbreviationConcentrations tested in vitroConcentrations found in human samples
Lead(II) chlorideLead200, 50, 12.50, 3.13, 0.78, 0.20 μMCord blood:
range 1.09–11.41 μg/L ➔0.0039–0.041 μM
Children blood:
Range 1.71–10 μg/dL ➔0.061–0.36 μM
IPChem:
Blood-whole blood: 3.76–69, 3.42–28.8, 4.13–43.6, 6.05–23.1 μg/L (range 3.42–69) ➔ 0.012–0.25 μM
Cord blood-whole blood (considering for plasma, 1.025 g/mL) 2.68–36.4 ng/g ➔ 0.00988–0.13 μM
ChlorpyrifosCPF500, 125, 31.25, 7.81, 1.95, 0.49 μMCord plasma:
4.65 ng/mL ➔ 0.013 μM
Cord blood:
Range 2.5–6.17 pg/g plasma (considering for plasma, 1.025 g/mL) ➔ 7.3 × 10− 6 - 1.8 × 10− 5 μM
Bisphenol ABPA400, 100, 25, 6.25, 1.56, 0.39, 0.10 μMChildren serum:
Range 0.85–22.5 ng/mL ➔ 0.0037–0.098 μM
IPChem:
Blood – plasma: n.d.- 3.5 ng/g (considering for plasma, 1.025 g/mL) ➔ n.d. - 0.016 μM
Cord blood-whole blood: n.d.-1.9 ng/g (considering for plasma, 1.025 g/mL) ➔ n.d. - 0.0085 μM
Methyl-mercury(II) chlorideMethyl-Hg10, 2.50, 0.63, 0.16, 0.04, 0.01, 0.0024, 0.0006 μMCord blood:
range 0.70–35 μg/L ➔ 0.0028–0.14 μM
Children blood:
Range 1.46–6.81 μg/L ➔ 0.0058–0.027 μM
IPChem:
Blood-whole blood: 0.11–10.2, 0.002–4.17, 0.19–7.93, 0.13–5.95 μg/L (range 0.002–10.2) ➔ 8 × 10− 6 - 0.041 μM
Cord blood-whole blood: 0.16–14.1 ng/g (considering for plasma, 1.025 g/mL) ➔0.00065–0.058 μM
Cord blood-whole blood: n.d. - 8.4 μg/L ➔ n.d.-0.033 μM
Blood –plasma: n.d. - 4.2 μg/L ➔ n.d.- 0.017 μM
Valproic acidVA10.000, 2500, 625, 156, 39, 10 μMCord blood:
Range 3.87–75 μg/ml ➔ 26.8–520 μM
PCB138PCB138100, 25, 6.25, 1.56, 0.39, 0.10, 0.02 μMCord plasma:
Range 0.14–0.18 ng/mL ➔ 3.87 × 10− 4 - 5 × 10− 4 μM
IPChem:
cord plasma: 270–460 ng/L ➔ 0.00075–0.0013 μM