Table 3 LOAECs specific for each time interval and DNT endpoint and their serial dilutions tested in Phase 3

3 days

BPA

CPF

Lead

Methyl-Hg

PCB138

VA

(μM)

Synaptogenesis

28.96

37.1

0.007

0.26

5.93

420

LOAEC-syn

14.48

18.55

0.004

0.13

2.97

210

LOAEC/2-syn

7.24

9.28

0.002

0.07

1.48

105

LOAEC/4-syn

Neurite outgrowth

12.74

74.2

1.46

0.26

0.06

70

LOAEC-neu

6.37

37.1

0.73

0.13

0.03

35

LOAEC/2-neu

3.19

18.55

0.37

0.07

0.015

17.5

LOAEC/4-neu

BDNF levels

57.92

37.1

1.46

0.26

0.06

420

LOAEC-bdnf

28.96

18.55

0.73

0.13

0.03

210

LOAEC/2-bdnf

14.48

9.28

0.37

0.07

0.015

105

LOAEC/4-bdnf

14 days

BPA

CPF

Lead

Methyl-Hg

PCB138

VA

(μM)

Synaptogenesis

12.74

21.01

0.007

0.05

0.06

2.1

LOAEC-syn

6.37

10.51

0.004

0.025

0.03

1.05

LOAEC/2-syn

Neurite outgrowth

12.74

74.2

1.46

0.13

11.86

420

LOAEC-neu

6.37

37.1

0.73

0.07

5.93

210

LOAEC/2-neu

3.19

18.55

0.37

0.03

2.97

105

LOAEC/4-neu

1.59

9.28

0.18

0.016

1.48

52.5

LOAEC/8-neu

BDNF levels

12.74

37.1

1.46

0.13

3.53

210

LOAEC-bdnf

6.37

18.55

0.73

0.07

1.77

105

LOAEC/2-bdnf

3.19

9.28

0.37

0.03

0.88

52.5

LOAEC/4-bdnf