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Table 3 LOAECs specific for each time interval and DNT endpoint and their serial dilutions tested in Phase 3

From: Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept

3 daysBPACPFLeadMethyl-HgPCB138VA(μM)
Synaptogenesis28.9637.10.0070.265.93420LOAEC-syn
14.4818.550.0040.132.97210LOAEC/2-syn
7.249.280.0020.071.48105LOAEC/4-syn
Neurite outgrowth12.7474.21.460.260.0670LOAEC-neu
6.3737.10.730.130.0335LOAEC/2-neu
3.1918.550.370.070.01517.5LOAEC/4-neu
BDNF levels57.9237.11.460.260.06420LOAEC-bdnf
28.9618.550.730.130.03210LOAEC/2-bdnf
14.489.280.370.070.015105LOAEC/4-bdnf
14 daysBPACPFLeadMethyl-HgPCB138VA(μM)
Synaptogenesis12.7421.010.0070.050.062.1LOAEC-syn
6.3710.510.0040.0250.031.05LOAEC/2-syn
Neurite outgrowth12.7474.21.460.1311.86420LOAEC-neu
6.3737.10.730.075.93210LOAEC/2-neu
3.1918.550.370.032.97105LOAEC/4-neu
1.599.280.180.0161.4852.5LOAEC/8-neu
BDNF levels12.7437.11.460.133.53210LOAEC-bdnf
6.3718.550.730.071.77105LOAEC/2-bdnf
3.199.280.370.030.8852.5LOAEC/4-bdnf