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Fig. 5 | Environmental Health

Fig. 5

From: Perinatal oral exposure to low doses of bisphenol A, S or F impairs immune functions at intestinal and systemic levels in female offspring mice

Fig. 5

Perinatal exposure to BPA or BPF provokes systemic Th1/Th17 immune response in adult offspring mice. Flow cytometry analysis of Th1 CD3+IFN-γ+T-bet+ (a) or Th17 CD3+RORγt+IL-17+ (c) lymphocytes from spleen. IFN-γ (b) or IL-17 (d) level assessed by ELISA after anti-CD3/CD28 in vitro restimulation of isolated lymphocytes from splenic offspring mice at PND70. (e) Proportion of CD4+CD25+FoxP3+ Treg cells in spleen of offspring mice at PND70. * P < 0.05; ** P < 0.01; *** P < 0.001 vs. vehicle group. n = 5–14

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