Table 3 Percent (%) difference in placental PBDE levels between molecular immunoreactivity groups for each biomarker within each placental region/cell type during mid-gestation (n = 62)
|  |  | Wet-weight BDE-47 (ng/g) | Wet-weight ∑PBDE4 (ng/g) | Lipid-adjusted BDE-47 (ng/g lipid) | Lipid-adjusted ∑PBDE4 (ng/g lipid) | ||||
|---|---|---|---|---|---|---|---|---|---|
Immunoreactivity | n | % diff (95% CI)a | p-valueb | % diff (95% CI)a | p-valueb | % diff (95% CI)a | p-valueb | % diff (95% CI)a | p-valueb |
Anchoring Villi (proximal) | |||||||||
ITGA1 < 25% (−) | 48 | Referent | 0.616 | Referent | 0.433 | Referent | 0.813 | Referent | 0.724 |
 25–75% (−/+) | 2 | 68 (−44, 403) |  | 82 (−32, 385) |  | 38 (−56, 331) |  | 49 (− 46, 316) |  |
  > 75% (+) | 2 | −16.(−72, 151) |  | −21 (−70, 110) |  | 23 (−61, 283) |  | 15 (−59, 221) |  |
CHD5 < 25% (−) | 11 | Referent | 0.502 | Referent | 0.404 | Referent | 0.441 | Referent | 0.357 |
 25–75% (−/+) | 21 | 35 (−20, 130) |  | 39 (−14, 125) |  | 39 (−20, 142) |  | 43 (−13, 136) |  |
  > 75% (+) | 21 | 13 (−34, 91) |  | 21 (−25, 94.8) |  | 11 (−36, 93) |  | 19 (−28, 96) |  |
MMP1 < 25% (−) | 1 | Referent | 0.395 | Referent | 0.472 | Referent | 0.741 | Referent | 0.862 |
 25–75% (−/+) | 30 | 109 (−51, 797) |  | 56 (−58, 481) |  | 69 (−64, 700) |  | 26 (−69, 413) |  |
  > 75% (+) | 20 | 67 (−61, 626) |  | 2 (−6, 375) |  | 51 (−69, 627) |  | 14 (−72, 371) |  |
Anchoring Villi (distal) | |||||||||
ITGA1 < 25% (−) | 38 | Referent | 0.759 | Referent | 0.837 | Referent | 0.599 | Referent | 0.739 |
 25–75% (−/+) | 3 | −19 (−68, 102) |  | 4.1 (−54, 138) |  | −28 (−72, 83) |  | − 7.8 (− 61, 116) |  |
  > 75% (+) | 11 | 15 (−32, 94) |  | 15 (−28, 85) |  | 19 (−30, 104) |  | 20 (−26, 95) |  |
CHD5 < 25% (−) | 9 | Referent | 0.670 | Referent | 0.550 | Referent | 0.662 | Referent | 0.542 |
 25–75% (−/+) | 24 | 29 (−26, 125) |  | 32 (−20, 120) |  | 31 (−27, 135) |  | 35 (−21, 128) |  |
  > 75% (+) | 20 | 17 (−34, 108) |  | 19 (−29, 100) |  | 19 (−35, 117) |  | 21 (−30, 108) |  |
MMP1 < 25% (−) | 0 | Referent | 0.901 | Referent | 0.944 | Referent | 0.661 | Referent | 0.697 |
 25–75% (−/+) | 25 | −9.1 (−40, 37) |  | −6.2 (− 35, 36) |  | −18 (−47, 26) |  | −15 (−43, 24) |  |
> 75% (+) | 26 | – |  | – |  | 0.0 (0.0, 0.0) |  | 0.0 (0.0, 0.0) |  |
Interstitial CTB | |||||||||
ITGA1 < 25% (−) | 6 | Referent | 0.622 | Referent | 0.556 | Referent | 0.881 | Referent | 0.863 |
 25–75% (−/+) | 24 | −16 (−58, 66) |  | −17.1 (−55, 53) |  | −3.5 (−53, 98) |  | −4.4 (−49, 81) |  |
  > 75% (+) | 30 | 2.3 (−48, 101) |  | 1.07 (−45, 85) |  | 7.6 (−47, 117) |  | 6.3 (−43, 99) |  |
CHD5 < 25% (−) | 8 | Referent | 0.032** | Referent | 0.028** | Referent | 0.018** | Referent | 0.019** |
 25–75% (−/+) | 14 | 138 (26, 350)*** |  | 115 (22, 279)*** |  | 163 (37, 405)*** |  | 137 (33, 325)*** |  |
  > 75% (+) | 38 | 63 (−6.6, 185)* |  | 42 (−14, 133) |  | 102 (14, 257)** |  | 75 (5.3, 192)** |  |
MMP1 < 25% (−) | 2 | Referent | 0.372 | Referent | 0.350 | Referent | 0.693 | Referent | 0.727 |
 25–75% (−/+) | 23 | 41 (−53, 324) |  | −0.38 (−63, 167) |  | 36 (−57, 330) |  | −4.1 (− 66, 168) |  |
  > 75% (+) | 35 | 77 (−40, 425) |  | 29 (−51, 242) |  | 53 (−51, 376) |  | 12 (−59, 208) |  |
Endovascular CTB | |||||||||
ITGA1 < 25% (−) | 6 | Referent | 0.303 | Referent | 0.211 | Referent | 0.518 | Referent | 0.386 |
 25–75% (−/+) | 5 | −30 (−73, 80) |  | −22 (−65, 73) |  | −9.3 (− 66, 145) |  | 1.0 (−57, 135) |  |
  > 75% (+) | 18 | −44 (−73, 16) |  | − 42 (−69, 7.2)* |  | −34 (− 69, 44) |  | − 31 (− 64, 32) |  |
CHD5 < 25% (−) | 8 | Referent | 0.256 | Referent | 0.175 | Referent | 0.145 | Referent | 0.151 |
 25–75% (−/+) | 3 | 140 (−16, 590) |  | 146 (−2.8, 521)* |  | 134 (−21, 588) |  | 139 (−8.3, 522)* |  |
  > 75% (+) | 31 | 42 (−24, 162) |  | 23 (−29, 112) |  | 82.4 (−3.2, 243) |  | 59 (−9.5, 178) |  |
MMP1 < 25% (−) | 11 | Referent | 0.883 | Referent | 0.846 | Referent | 0.847 | Referent | 0.736 |
 25–75% (−/+) | 20 | 12 (−40, 110) |  | 1.1 (−42, 77) |  | 8.0 (− 43, 106) |  | −2.8 (−45, 73) |  |
  > 75% (+) | 5 | −6.6 (−6, 130) |  | −19 (−64, 83) |  | −16 (−67, 113) |  | −27 (− 68, 67) |  |