Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function

Table 3 Associations between oxidative damage and lung function parameters (N = 3367)

Oxidative damage	Lung function parameters	Estimated changes (95% CI) by continuous OH-PAHs	Estimated changes in ml (95% CI) by quartile of oxidative damage				P value for trend^a
Oxidative damage	Lung function parameters	Estimated changes (95% CI) by continuous OH-PAHs	Quartile 1	Quartile 2	Quartile 3	Quartile 4	P value for trend^a
8-OHdG			< 28.79	28.79–63.18	63.18–125.04	≥125.04
	FEV₁	−6.08 (− 17.28, 5.11)	0 (referent)	−8.51 (− 45.57, 28.55)	− 10.00 (− 47.14, 27.15)	−21.92 (− 59.30, 15.45)	0.2651
	FVC	− 17.48 (− 31.08, − 3.88)	0 (referent)	− 16.98 (− 62.01, 28.06)	−17.65 (− 62.79, 27.49)	−46.03 (− 90.65, − 1.41)	0.0430
8-iso-PGF2α			< 109.09	109.09–176.89	176.89–310.79	≥310.79
	FEV₁	−11.31 (− 29.56, 6.93)	0 (referent)	3.25 (−32.62, 39.13)	−8.71 (− 44.37, 26.96)	−13.57 (− 50.12, 22.98)	0.4241
	FVC	−16.15 (− 38.38, 6.07)	0 (referent)	3.57 (−40.06, 47.20)	− 19.90 (− 63.26, 23.45)	−26.93 (− 71.51, 17.65)	0.1813

Model adjusted for age (continuous variable), gender (male/female), height (continuous variable), weight (continuous variable), smoking amounts (continuous variable), passive smoking status (yes/no), drinking status (yes/no), education level (categorical variable), annual family income (categorical variable), regular physical activity (yes/no), cooking meals at home (yes/no), sleep duration at night (continuous variable), eating smoked food (< 1/≥1 time/week), eating vegetables or fruits (< 1/≥1 time/day), eating aquatic products (< 1/≥1 time/day) and city (Wuhan/Zhuhai)
Abbreviations: 8-iso-PGF2α 8-isoprostane, 8-OHdG 8-hydroxy-2′-deoxyguanosine, CI Confidence interval, FEV₁ Forced expiratory volume in 1 s, FVC Forced vital capacity
^aP trend values of the quartile coefficients were estimated by including the original log-transformed oxidative damage as a continuous variable

ISSN: 1476-069X