Skip to main content

Table 3 Associations between maternal plasma PFAS concentrations (ng/mL) and thyroid hormones in cord plasma by linear regression models

From: Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort

PFAS

T3 (nmol/L)

FT3 (pmol/L)

T4 (nmol/L)

FT4(pmol/L)

TSH (uIU/mL)

Crude β (95% CI)

Adjust β (95% CI)

Crude β (95% CI)

Adjust β (95% CI)

Crude β (95% CI)

Adjust β (95% CI)

Crude β (95% CI)

Adjust β (95% CI)

Crude β (95% CI)

Adjust β (95% CI)

PFHxS

0.00 (−0.05, 0.04)

0.00 (− 0.05, 0.04)

0.01 (− 0.10, 0.12)

0.02 (− 0.08, 0.13)

−1.70 (−9.10, 5.70)

− 0.59 (−7.94, 6.76)

−0.35 (− 0.89, 0.20)

− 0.32 (− 0.87, 0.22)

0.07 (− 1.45, 1.59)

0.43 (− 1.02, 1.88)

PFOS

0.05 (0.02, 0.08)*

0.05 (0.02, 0.08) *

0.07 (0.00, 0.15) *

0.09 (0.02, 0.16) *

−4.49 (− 9.68, 0.70)

−3.64 (−8.85, 1.56)

0.04 (− 0.34, 0.43)

0.06 (− 0.33, 0.45)

− 1.06 (−2.12, 0.00)

−0.71 (− 1.74, 0.31)

PFOA

0.06 (0.02, 0.11) *

0.07 (0.02, 0.11) *

0.13 (0.03, 0.23) *

0.13 (0.03, 0.23) *

−2.56 (− 9.48, 4.36)

− 1.18 (− 8.14, 5.79)

0.03 (− 0.48, 0.54)

0.08 (− 0.44, 0.59)

0.37 (− 1.05, 1.79)

0.86 (− 0.50, 2.23)

PFNA

0.04 (0.01, 0.08) *

0.05 (0.01, 0.09) *

0.02 (− 0.08, 0.11)

0.01 (− 0.08, 0.10)

−7.93 (− 14.43, − 1.42) *

−7.81 (− 14.38, − 1.24) *

− 0.34 (− 0.82, 0.14)

− 0.39 (− 0.88, 0.10)

−1.86 (− 3.20, − 0.53) *

−1.61 (− 2.90, − 0.31) *

PFDA

0.06 (0.03, 0.08) *

0.06 (0.03, 0.09) *

0.07 (0.01, 0.14) *

0.08 (0.01, 0.15) *

−5.40 (−10.09, − 0.71) *

−5.07 (− 9.78, − 0.37) *

− 0.10 (− 0.45, 0.25)

−0.10 (− 0.45, 0.26)

−1.07 (− 2.03, − 0.11) *

−0.96 (− 1.89, − 0.03) *

PFUdA

0.05 (0.02, 0.08) *

0.05 (0.03, 0.08) *

0.05 (− 0.01, 0.12)

0.06 (− 0.01, 0.12)

− 5.09 (− 9.66, − 0.53) *

−4.90 (− 9.44, − 0.35) *

−0.11 (− 0.45, 0.23)

−0.11 (− 0.45, 0.23)

− 1.11 (− 2.04, − 0.17) *

−1.06 (− 1.95, − 0.16) *

PFDoA

0.02 (0.00, 0.03) *

0.02 (0.00, 0.04) *

0.01 (−0.03, 0.05)

0.01 (− 0.03, 0.05)

−1.16 (− 3.88, 1.56)

−1.42 (− 4.15, 1.30)

0.03 (− 0.17, 0.23)

0.00 (− 0.20, 0.20)

−0.42 (− 0.98, 0.13)

−0.43 (− 0.97, 0.10)

PFTrDA

0.01 (− 0.01, 0.03)

0.01 (− 0.01, 0.03)

0 .00 (− 0.04, 0.04)

0.01 (− 0.03, 0.05)

− 2.37 (− 5.20, 0.47)

− 1.70 (− 4.54, 1.15)

−0.09 (− 0.30, 0.11)

−0.08 (− 0.29, 0.13)

−0.61 (− 1.19, − 0.03) *

−0.43 (− 0.99, 0.13)

  1. PFAS concentrations were ln-transformed in the models; adjusted for maternal age at delivery, pre-pregnancy BMI, education, parity, gestational age, delivery type, infant’ sex, maternal passive smoking during pregnancy, maternal folic acid supplement, and paternal drinking during 3 months before pregnancy
  2. *P < 0.05
Back to article page

Environmental Health

ISSN: 1476-069X