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Table 3 Associations between maternal plasma PFAS concentrations (ng/mL) and thyroid hormones in cord plasma by linear regression models

From: Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort

PFAS T3 (nmol/L) FT3 (pmol/L) T4 (nmol/L) FT4(pmol/L) TSH (uIU/mL)
Crude β (95% CI) Adjust β (95% CI) Crude β (95% CI) Adjust β (95% CI) Crude β (95% CI) Adjust β (95% CI) Crude β (95% CI) Adjust β (95% CI) Crude β (95% CI) Adjust β (95% CI)
PFHxS 0.00 (−0.05, 0.04) 0.00 (− 0.05, 0.04) 0.01 (− 0.10, 0.12) 0.02 (− 0.08, 0.13) −1.70 (−9.10, 5.70) − 0.59 (−7.94, 6.76) −0.35 (− 0.89, 0.20) − 0.32 (− 0.87, 0.22) 0.07 (− 1.45, 1.59) 0.43 (− 1.02, 1.88)
PFOS 0.05 (0.02, 0.08)* 0.05 (0.02, 0.08) * 0.07 (0.00, 0.15) * 0.09 (0.02, 0.16) * −4.49 (− 9.68, 0.70) −3.64 (−8.85, 1.56) 0.04 (− 0.34, 0.43) 0.06 (− 0.33, 0.45) − 1.06 (−2.12, 0.00) −0.71 (− 1.74, 0.31)
PFOA 0.06 (0.02, 0.11) * 0.07 (0.02, 0.11) * 0.13 (0.03, 0.23) * 0.13 (0.03, 0.23) * −2.56 (− 9.48, 4.36) − 1.18 (− 8.14, 5.79) 0.03 (− 0.48, 0.54) 0.08 (− 0.44, 0.59) 0.37 (− 1.05, 1.79) 0.86 (− 0.50, 2.23)
PFNA 0.04 (0.01, 0.08) * 0.05 (0.01, 0.09) * 0.02 (− 0.08, 0.11) 0.01 (− 0.08, 0.10) −7.93 (− 14.43, − 1.42) * −7.81 (− 14.38, − 1.24) * − 0.34 (− 0.82, 0.14) − 0.39 (− 0.88, 0.10) −1.86 (− 3.20, − 0.53) * −1.61 (− 2.90, − 0.31) *
PFDA 0.06 (0.03, 0.08) * 0.06 (0.03, 0.09) * 0.07 (0.01, 0.14) * 0.08 (0.01, 0.15) * −5.40 (−10.09, − 0.71) * −5.07 (− 9.78, − 0.37) * − 0.10 (− 0.45, 0.25) −0.10 (− 0.45, 0.26) −1.07 (− 2.03, − 0.11) * −0.96 (− 1.89, − 0.03) *
PFUdA 0.05 (0.02, 0.08) * 0.05 (0.03, 0.08) * 0.05 (− 0.01, 0.12) 0.06 (− 0.01, 0.12) − 5.09 (− 9.66, − 0.53) * −4.90 (− 9.44, − 0.35) * −0.11 (− 0.45, 0.23) −0.11 (− 0.45, 0.23) − 1.11 (− 2.04, − 0.17) * −1.06 (− 1.95, − 0.16) *
PFDoA 0.02 (0.00, 0.03) * 0.02 (0.00, 0.04) * 0.01 (−0.03, 0.05) 0.01 (− 0.03, 0.05) −1.16 (− 3.88, 1.56) −1.42 (− 4.15, 1.30) 0.03 (− 0.17, 0.23) 0.00 (− 0.20, 0.20) −0.42 (− 0.98, 0.13) −0.43 (− 0.97, 0.10)
PFTrDA 0.01 (− 0.01, 0.03) 0.01 (− 0.01, 0.03) 0 .00 (− 0.04, 0.04) 0.01 (− 0.03, 0.05) − 2.37 (− 5.20, 0.47) − 1.70 (− 4.54, 1.15) −0.09 (− 0.30, 0.11) −0.08 (− 0.29, 0.13) −0.61 (− 1.19, − 0.03) * −0.43 (− 0.99, 0.13)
  1. PFAS concentrations were ln-transformed in the models; adjusted for maternal age at delivery, pre-pregnancy BMI, education, parity, gestational age, delivery type, infant’ sex, maternal passive smoking during pregnancy, maternal folic acid supplement, and paternal drinking during 3 months before pregnancy
  2. *P < 0.05