Table 6 Interaction between noise kurtosis and rs12195525 polymorphism for the risk of NIHL
Genotypes | Steady noise (β < 10) | Complex noise (β ≥ 10) | OR (95% CI) for complex noise within strata of genotype | RERI (95%CI) | P value | ||
|---|---|---|---|---|---|---|---|
NIHL/Control (n) | OR (95%CI) | NIHL/Control (n) | OR (95%CI) | ||||
rs12195525 |  |  |  |  |  | −0.307(−2.884–2.270) | 0.815 |
 Non-risk genotype (TT + GT) | 4/16 |  | 36/42 |  |  |  |  |
|  | 1 |  | 3.429 (1.051–11.187) | 3.429 (1.051–11.187) |  |  | |
|  |  |  | P = 0.041 | P = 0.041 |  |  | |
 Risk genotype (GG) | 57/77 |  | 210/172 |  |  |  |  |
|  | 2.961 (0.940–9.332) |  | 4.884 (1.603–14.879) | 1.726 (1.146–2.600) |  |  | |
|  | P = 0.064 |  | P = 0.005 | P = 0.009 |  |  | |
OR (95% CI) for risk genotype within strata of kurtosis |  | 2.961 (0.940–9.332) |  | 1.495 (0.911–2.455) |  |  |  |
|  | P = 0.064 |  | P = 0.112 |  |  |  | |