Skip to main content

Table 2 Negative binomial regression analysis of the association between osmolality adjusted maternal BPA exposure divided into tertiles and the incidence rate ratio (IRR) and 95% confidence intervals (CI 95%) of ADHD-score in boys and girls at 2 and 5 years of age

From: Prenatal exposure to bisphenol A and autistic- and ADHD-related symptoms in children aged 2 and5 years from the Odense Child Cohort

Osmolality adjusted BPA (ng/mL)

Adjusteda IRR (CI 95%)

All (N = 654)

Adjusteda IRR (CI 95%) Boys (N = 347)

Adjusteda IRR (CI 95%) Girls (N = 307)

ASD-score at 2 years

 1th tertile (≤0.87)

Reference

Reference

Reference

 2nd tertile (0.88–1.96)

0.87 (0.71–1.07)

0.85 (0.65–1.10)

0.89 (0.64–1.24)

 3rd tertile (≥ 1.97)

1.02 (0.84–1.24)

1.08 (0.84–1.39)

0.91 (0.66–1.25)

 p-trendb

0.80

0.48

0.54

Osmolality adjusted BPA (ng/mL)

Adjusteda IRR (CI 95%)

All (N = 425)

Adjusteda IRR (CI 95%) Boys (N = 223)

Adjusteda IRR (CI 95%) Girls (N = 202)

ASD-score 5 years

 1st tertile (≤0.87)

Reference

Reference

Reference

 2nd tertile (0.88–1.96)

1.13 (0.89–1.42)

1.09 (0.80–1.51)

1.18 (0.58–5.54)

 3rd tertile (≥ 1.97)

1.23 (0.98–1.53)

1.20 (0.88–1.63)

1.29 (0.93–1.78)

 p-trendb

0.07

0.24

0.13

Osmolality adjusted BPA (ng/mL)

Adjusteda IRR (CI 95%)

All (N = 425)

Adjusteda IRR (CI 95%) Boys (N = 223)

Adjusteda IRR (CI 95%) Girls (N = 202)

ADHD-score at 5 years

 1st tertile (≤0.87)

Reference

Reference

Reference

 2nd tertile (0.88–1.96)

0.96 (0.76–1.22)

0.88 (0.66–1-17)

1.11 (0.75–1.65)

 3rd tertile (≥ 1.97)

1.08 (0.86–1.35)

0.98 (0.75–1.30)

1.26 (0.87–1.85)

 p-trendb

0.86

0.43

0.76

  1. aAnalyses adjusted for maternal education, maternal age, pre-pregnancy BMI, child age at evaluation, parity. The sex-combined analyses were additionally adjusted for child sex
  2. bTrend across tertiles tested by inserting the tertile osmolality adjusted BPA as an ordinal indicator variable (0,1,2)
  3. * P-value < 0.05