Table 4 Association between exposure to traffic related air pollutants in early life and asthma development
References | Type of study, Country | Subjects, no | Pollutant and exposure assessment | Outcome | Positive association with the outcome |
|---|---|---|---|---|---|
To T et al., 2020 [27] | T-CHEQ registry-based birth cohort, Ontario, Canada | 1286 | PM2.5, NO2 Average exposure assessed in the first 3 years of life | Asthma (birth up to 15–20 years) | Yes only for NO2 |
Jung CR et al., 2019 [15] | TMCHD registry-based birth cohort, Taiwan | 184,604 | PM2.5 Exposure assessed in the first year of life | Asthma (birth up to 3–10 years) | Yes |
Lavigne E et al. 2018 [16] | Registry-based birth cohort Ontario, Canada | 222,864 | PM2.5, NO2 Exposure assessed in the first year of life | Asthma (birth up to < 6 years) | Yes only for NO2 |
Pennington AF et al., 2018 [17] | KAPPA registry- based birth cohort, Atlanta, USA | 23,100 | PM2.5, NOx, CO Annual average exposure estimated in the first year of life | Asthma (2 to 6 years) | Yes |
Rancière F et al., 2017 [22] | PARIS birth cohort, France | 2015 | NOx Exposure assessed in the first year of life | Asthma (birth up to 4 years) | Yes |
Tétreault L-F et al., 2016 [28] | Registry-based birth cohort, Quebec, Canada | 1,183,865 | PM2.5, NO2 Annual average exposure estimated at birth address | Asthma (birth up to 1–12 years) | Yes |
Gehring U et al., 2015 [30] | PIAMA birth cohort, the Netherlands | 3702 | PM2.5 abs, PM2.5, PM10, PM coarse, NO2, elemental composition of PM2.5 and PM10 Annual average exposure estimated at birth address | Asthma (birth up to 11 years) | Yes only for NO2, K PM2.5, K PM10, S PM2.5, Zn PM10 |
Gehring U et al., 2015 [29] | BAMBSE, GINI plus, LISA plus and PIAMA birth cohorts, Sweden, Germany, the Netherlands | 14,126 | PM2.5 abs, PM2.5, PM10, PM coarse, NO2 Annual average exposure estimated at birth address | Asthma (birth up to 14–16 years) | Yes only for NO2, PM2.5 abs |
Ranzi A et al., 2014 [31] | GASPII birth cohort, Italy | 672 | NO2 Annual average exposure estimated at birth address | Asthma (birth up to 7 years) | No |
Fuertes E et al., 2013 [32] | GINI plus and LISA plus birth cohorts, Germany | 6604 | PM2.5 mass, PM2.5 abs, NO2 Annual average exposure estimated at birth address | Asthma (birth up to 10 years) | No |
Gruzieva O et al., 2013 [33] | BAMSE birth cohort, Sweden | 3633 | NOx, PM10 Annual average exposure estimated at birth address | Asthma (birth up to 12 years) | Yes |
Lindgren A et al., 2013 [34] | Registry-based birth cohort, southern Sweden | 7898 | NOx Annual average exposure estimated at birth address | Asthma (birth up to 1–6 years) | Negative association |
Clark NA et al., 2010 [35] | Case-control study, nested in a cohort (administrative databases), British Columbia, Canada | 3482 cases, 17,410 controls | PM2.5, PM10, NO, NO2, CO, BC Exposure estimated at address in the first year of life | Asthma (birth up to 36–59 months) | Yes only for NO2, BC, CO, PM10 |
Gehring U et al., 2010 [23] | PIAMA birth cohort, the Netherlands | 3863 | PM2.5, NO2, Soot Annual average exposure estimated at birth address | Asthma (birth up to 8 years) | Yes |