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Table 2 WoE categories for lines of evidence assessment

From: Assessment of the endocrine disrupting properties of bisphenol AF: a case study applying the European regulatory criteria and guidance

Category Principles for categorization
Strong ■Effects were observed in one or more studies of high reliability; there are no conflicting results.
Moderate ■Effects were observed in one study of partial reliability, or
■effects were observed in two or more studies of partial reliability; there are no conflicting results, or
■effects were observed in one or more studies of high or partial reliability but with conflicting results, i.e., no or opposite effects were observed in other studies. However, conflicts of results can be explained by differences in study design, for example different exposure periods, doses or animal species or cell models.
Weak ■Effects were observed in one or more studies of high or partial reliability but with conflicting results, i.e., no or opposite effects were observed in other studies. Conflicts of results cannot be explained by differences in study design, for example different exposure periods, doses or animal species or cell models, or
■effects were only observed in one or more studies of low reliability.