Lines of evidence ENDOCRINE ACTIVITY in mammals | ||
---|---|---|
Weight of Evidence | In vitro mechanistic | In vivo mechanistic |
Strong | ■Estrogen receptor binding-in silico IDs: 45, 51, 72, 75 ■Estrogen receptor binding and agonist activity IDs: 3, 6, 8, 11–15, 17–18, 20–22, 42–44, 46, 48, 52, 62–65, 78, 81, 86–87 ■Estrogen dependent cellular proliferation IDs: 7–6, 10, 15, 20, 48, 80 ■Estrogen receptor dependent gene/protein expression increased IDs: 9–13, 15, 17–18, 20, 23, 48, 80 ■Androgen receptor antagonist binding-in silico IDs: 75–76 ■Androgen receptor binding and antagonist activity IDs: 19, 21–22, 43, 64, 78, 81, 87 ■Steroidogenesis alteration IDs: 4–5, 87 ■Thyroid hormone receptor binding-in silico ID: 75 ■Thyroid hormone related gene expression decreased ID: 7 | ■Estrogen receptor dependent gene expression increased (adult and gestational exposure) IDs: 59, 83 ■Uterus weight increase (adult exposure) IDs: 61–63, 86 ■Uterus histopathology alteration (adult exposure) ID: 63 ■Steroidogenesis gene/protein expression alteration (adult and gestational exposure) IDs: 55, 58, 83 ■Estradiol level increase in female offspring (gestational exposure) ID: 59 ■Testosterone level decrease in male (adult exposure) ID: 55 ■Progesterone level increase in female offspring (gestational exposure) ID: 59 ■Progesterone level decrease in female (adult exposure) ID: 83 ■FSH level increase in male (adult exposure) ID: 55 ■LH level increase in male (adult exposure) ID: 55 ■T4 level increase (adult exposure) ID: 60 |
Moderate | ■Thyroid hormone receptor activity alteration IDs: 7–8, 21, 64 | ■Testosterone level increase in male offspring (gestational exposure) ID: 58 |
Weak | Â | â– Weight increase of male androgen-dependent sex accessory tissues (adult exposure ID: 61 â– Testosterone level decrease in female offspring (gestational exposure) ID: 59 |
No evidence for effect | Â | â– Estradiol level alteration in male offspring (gestational exposure) ID: 58 â– Estradiol level in female (adult exposure) ID: 83 â– Testosterone fetal production alteration (gestational exposure) ID: 56 â– FSH level alteration in female (adult exposure) ID: 83 â– FSH levels alteration in male offspring (gestational exposure) ID: 58 â– LH level alteration in male offspring (gestational exposure) ID: 58 â– TSH level alteration (adult exposure) ID: 60 |