Table 1 Characteristics at recruitment of EPIC cancer cases and sub-cohort participants

Center

0.035

< 0.001

 Gipuzkoa

1.239 (25.7)

123 (22.4)

467 (24.3)

225 (39.1)

424 (23.9)

 Granada

1159 (24.1)

116 (21.2)

501 (26.1)

63 (10.9)

479 (27.0)

 Murcia

1177 (24.4)

157 (28.7)

477 (24.8)

102 (17.7)

441 (24.8)

 Navarra

1237 (25.7)

151 (27.6)

473 (24.6)

185 (32.1)

428 (24.1)

Sex

–

575 (24.5)

1772 (75.5)

–

 Male

2347 (48.7)

–

–

 Female

2465 (51.2)

547 (22.2)

1918 (77.8)

–

–

Age

< 0.001

< 0.001

  < 45

936 (19.4)

174 (31.8)

367 (19.1)

34 (5.9)

361 (20.3)

 45–49

824 (17.1)

125 (22.8)

309 (16.1)

101 (17.5)

289 (16.3)

 50–54

994 (20.6)

96 (17.5)

399 (20.8)

120 (20.8)

379 (21.4)

 55–59

948 (19.7)

82 (14.9)

372 (19.4)

168 (29.2)

326 (18.4)

60+

1110 (23.1)

70 (12.8)

471 (24.5)

152 (26.4)

417 (23.5)

Education level

< 0.001

0.008

 None

1908 (39.9)

204 (37.6)

928 (48.7)

215 (37.5)

561 (31.9)

 Primary school

1696 (35.5)

221 (40.7)

677 (35.5)

207 (36.1)

591 (33.6)

 Technical school

363 (7.6)

33 (6.0)

92 (4.8)

46 (8.0)

192 (10.9)

 Secondary school

279 (5.8)

29 (5.3)

67 (3.5)

36 (6.2)

147 (8.3)

 University

531 (11.1)

55 (10.1)

141 (7.4)

69 (12.0)

266 (15.1)

 Unknown

35 (0.7)

BMI

< 0.001

0.475

 Normal weight

889 (18.6)

167 (30.5)

424 (22.11)

67 (11.6)

241 (13.6)

 Overweight

2401 (49.9)

214 (39.1)

826 (43.07)

341 (59.3)

1020 (34)

 Obese

1512 (31.4)

166 (30.3)

668 (34.83)

167 (29.0)

511 (28.8)

Smoking habit

< 0.001

0.110

 Never

2795 (58.1)

397 (72.5)

1584 (82.6)

205 (35.6)

609 (34.4)

 Former

903 (18.7)

51 (9.3)

136 (7.0)

156 (27.1)

560 (31.6)

 Smoker

1111 (23.1)

99 (18.1)

197 (10.2)

214 (37.2)

601 (33.9)

 Unknown

3 (0.1)

Physical activity

< 0.001

0.389

 Low

1077 (22.4)

54 (9.9)

100 (5.2)

210 (36.5)

713 (40.2)

 Medium

798 (16.6)

65 (11.9)

182 (8.5)

141 (24.5)

410 (23.1)

 High

1160 (24.1)

153 (28.0)

510 (26.6)

132 (23.0)

365 (20.6)

 Very high

1777 (8.54)

275 (50.3)

1126 (58.7)

92 (16.0)

284 (16.0)

Alcohol consumption

0.085

0.177

 None

1504 (31.3)

237 (43.3)

932 (48.5)

72 (12.5)

263 (14.8)

 Drinker

2329 (48.4)

272 (49.7)

874 (47.60)

280 (48.7)

903 (51.0)

 Heavy drinker

979 (20.3)

38 (6.9)

73 (3.81)

223 (38.8)

606 (34.2)

Menopausal status

< 0.001

 Premenopausal

906 (36.7)

276 (50.5)

630 (32.8)

 Postmenopausal

1188 (48.2)

193 (35.3)

995 (51.9)

 Perimenopausal

218 (8.8)

51 (9.3)

167 (8.7)

 Surgical Postmenopausal

153 (6.2)

27 (4.9)

126 (6.6)

Number of pregnancies

< 0.001

 0

253 (10.4)

67 (12.5)

186 (9.8)

 1–2

762 (31.4)

194 (36.2)

568 (30.)

 ≥3

1414 (58.2)

275 (51.3)

1139 (60.2)

 Unknown

36 (1.5)

Breastfeeding

0.010

 No

464 (19.1)

123 (22.9)

341 (18.0)

 Yes

1964 (80.9)

412 (77.1)

1551 (82.0)

 Unknown

37 (1.5)

Oral contraceptive ever

< 0.001

 No

1645 (66.7)

329 (30.1)

1316 (68.6)

 Yes

819 (33.2)

218 (39.9)

601 (31.4)

Unknown

1 (0.04)

Hormone replacement therapy

0.491

 No

2071 (87.7)

473 (88.6)

1598 (87.5)

 Yes

290 (12.3)

61 (11.4)

229 (12.5)

 Unknown

104 (4.2)