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Table 3 Odds ratios and 95% confidence intervals for TGCT associated with domestic use of pesticides during early periods of development, overall and according to histological subtypes, case-control study, N = 578, France, 2015–2018

From: Domestic use of pesticides during early periods of development and risk of testicular germ cell tumors in adulthood: a French nationwide case-control study

  Total Controls A + B All TGCT cases Non-Seminomas Seminomas P-HETb
(N = 578) (N = 274) (N = 304) (N = 132) (N = 144)
n (%) n (%) n (%) ORa (95% CI) n (%) ORa (95% CI) n (%) ORa (95% CI)
Domestic use of insecticides          0.12
 No 129 (22.3) 62 (22.6) 67 (22) 1.00 28 (21.2) 1.00 34 (23.6) 1.00  
 Yes 447 (77.3) 211 (77.0) 236 (77.6) 1.27 (0.80, 2.01) 104 (78.8) 1.78 (0.91, 3.48) 109 (75.7) 0.89 (0.50, 1.59)  
 Missing 2 (0.3) 1 (0.4) 1 (0.3) 0 (0.0) 1 (0.7)  
Domestic use of fungicides          0.08
 No 478 (82.7) 234 (85.4) 244 (80.3) 1.00 100 (75.8) 1.00 123 (85.4) 1.00  
 Yes 92 (15.9) 37 (13.5) 55 (18.1) 1.73 (1.04, 2.87) 31 (23.5) 2.44 (1.26, 4.74) 18 (12.5) 1.04 (0.52, 2.07)  
 Missing 8 (1.4) 3 (1.1) 5 (1.6) 1 (0.8) 3 (2.1)  
Domestic use of herbicides          0.17
 No 508 (87.9) 242 (88.3) 266 (87.5) 1.00 111 (84.1) 1.00 129 (89.6) 1.00  
 Yes 70 (12.1) 32 (11.7) 38 (12.5) 1.15 (0.67, 2.00) 21 (15.9) 1.64 (0.83, 3.27) 15 (10.4) 0.80 (0.37, 1.71)  
 Missing 0 (0.0) 0 (0) 0 (0.0) 0 (0.0) 0 (0.0)  
Domestic use of any pesticides          0.18
 No 119 (20.6) 57 (20.8) 62 (20.4) 1.00 25 (18.9) 1.00 32 (22.2) 1.00  
 Yes 456 (78.9) 215 (78.5) 241 (79.3) 1.18 (0.74, 1.88) 107 (81.1) 1.56 (0.79, 3.06) 111 (77.1) 0.84 (0.47, 1.51)  
 Missing 3 (0.5) 2 (0.7 1 (0.3) 0 (0.0) 1 (0.7)  
  1. OR odds ratios, CI confidence intervals
  2. a Estimates obtained comparing TGCT cases to group A and group B controls combined. Analysis was restricted to subjects with no missing data for the exposure variable (0.2 to 1.4% excluded)
  3. b P-value for heterogeneity derived from the Likelihood Ratio Test, comparing seminoma versus non-seminoma tumours