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Table 2 Serum metabolites associated with blood Pb in the 3rd trimester

From: Lead exposure and serum metabolite profiles in pregnant women in Mexico City

Metabolite subclass

Compounda

Estimate (SE)

P

Fatty acids and conjugates

Myristic acid

-0.073 (0.024)

2.63E-03

 

Stearic acid

-0.043 (0.014)

3.02E-03

 

Adrenic acid

-0.058 (0.019)

3.37E-03

 

Palmitoleic acid

-0.097 (0.032)

3.56E-03

 

Oleic acid / Elaidic acid / Petroselinic acid

-0.051 (0.020)

1.25E-02

 

Arachidonic acid

-0.040 (0.016)

1.52E-02

 

Lauric acid

-0.058 (0.023)

1.53E-02

 

Dihomo-Gamma-Linolenic acid

-0.040 (0.016)

1.69E-02

 

Margaric acid / Hexadecanol

-0.046 (0.020)

2.14E-02

 

Arachidic acid

-0.036 (0.016)

2.91E-02

 

Palmitic acid

-0.041 (0.014)

5.14E-03

 

Eicosapentaenoic acid

-0.049 (0.024)

4.40E-02

Amino acids, peptides, and analogues

5-Aminopentanoic acid

-0.137 (0.053)

1.16E-02

 

 N-Acetylalanine

-0.047 (0.019)

1.48E-02

 

Asparagine

-0.035 (0.016)

3.05E-02

 

 N-Acetylmethionine

-0.087 (0.042)

4.19E-02

 

Creatine

-0.064 (0.031)

4.00E-02

 

 L-Leucine

-0.039 (0.019)

4.16E-02

Purines and purine derivatives

Hypoxanthine

-0.047 (0.014)

1.26E-03*

 

7-Methylguanine

-0.015 (0.006)

1.70E-02

 

Caffeine

0.193 (0.080)

1.84E-02

Bile acids, alcohols and derivatives

Glycocholic acid

0.079 (0.035)

2.73E-02

 

Glycochenodeoxycholic acid

0.075 (0.038)

4.93E-02

Alpha hydroxy acids and derivatives

2-Hydroxybutyrate

-0.055 (0.016)

6.50E-04**

Dicarboxylic acids and derivatives

Succinate

-0.062 (0.024)

1.17E-02

Organosulfonic acids and derivatives

Taurine

-0.037 (0.015)

1.26E-02

Benzoic acids and derivatives

MBP (Mono-n-butyl phthalate)

-0.076 (0.036)

3.85E-02

Linoleic acids and derivatives

Alpha-linolenic acid (ALA) / Gamma-Linolenic acid (GLA)

-0.079 (0.032)

1.50E-02

Monoacylglycerols

1-Arachidonoylglycerol

0.066 (0.021)

2.83E-03

Other

N6-(Delta2-Isopentenyl)-Adenine

-0.049 (0.017)

4.16E-03

 

 N-Acetylneuraminic acid

-0.087 (0.042)

4.40E-02

  1. *Significant at thresholds of ENT75% and **ENT95%;Significantly-enriched (Holm-Bonferroni p < 0.05) subclass from enrichment analysis in MetaboAnalyst; aMetabolites were identified at MSI Level 1 confidence; compounds that co-eluted and could not be discriminated are indicated with “/” (MSI Level 2 confidence)